HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	24642916, 11489943
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 370
+	Hs
		665937 PTN6_HUMAN (1-595): 0: 628: 100.00		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		532361 PTN6_HUMAN (1-595): 0: 628: 100.00		CEAM1_HUMAN (8-323): 2.01e-48: 172: 17.47
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 628: 100.00		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		441208 PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		1031992 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		489970 PTPRF_HUMAN (93-516): 1.07e-112: 372: 26.98		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		573657 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		68228 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		HECA2_HUMAN (18-355): 2.35e-32: 128: 13.26
+	Hs
		68222 PTPRF_HUMAN (93-516): 1.07e-112: 372: 26.98		HECA2_HUMAN (18-355): 2.35e-32: 128: 13.26
+	Hs
		1031133 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		685236 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		CEAM8_HUMAN (55-250): 2.04e-18: 87.3: 12.25
+	Hs
		441196 PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		416911 PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Mm
		530202 PTPRA_MOUSE (125-516): 1.21e-107: 344: 27.14		NCAM1_MOUSE (5-352): 1.69e-20: 95.4: 11.59
+	Mm
		682309 PTN12_MOUSE (218-575): 3.21e-115: 362: 32.42		CEAM1_MOUSE (71-211): 1.25e-11: 67.7: 18.44
+	Hs
		448945 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		CD48_HUMAN (28-247): 2.6e-46: 160: 22.42
+	Hs
		1069952 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		PXDN_HUMAN (9-312): 1.02e-33: 134: 12.93
+	Hs
		685244 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		CEAM8_HUMAN (55-250): 2.04e-18: 87.3: 12.25
+	Hs
		1069962 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		LRIG1_HUMAN (13-128): 4.56e-11: 66.5: 17.24
+	Hs
		962520 PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43		PSG9_HUMAN (19-221): 1.71e-16: 82.3: 13.08