Protein: IBP3
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)

Gene: IBP3, IGFBP3
Organism: Homo sapiens
Interactions: 62
UniProt ID: P17936

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001558 - regulation of cell growth
GO:0001649 - osteoblast differentiation
GO:0001933 - negative regulation of protein phosphorylation
GO:0001968 - fibronectin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

420272

IGF1
Insulin-like growth factor 1

7

10

Small-scale

0.963

High

377816

IGF2
Insulin-like growth factor 2

5

10

Small-scale

0.919

High

609866

ALS
Insulin-like growth factor-binding protein complex acid labile subunit

2

2

Small-scale

0.778

High

390860

TRFE
Serotransferrin

1

0

Small-scale

0.687

High

389003

FINC
Fibronectin

2

5

Small-scale

0.636

High

209873

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

3

Small-scale

0.625

High

609859

IBP3
Insulin-like growth factor-binding protein 3

1

12

Small-scale

0.618

High

384106

CO1A1
Collagen alpha-1(I) chain

1

5

Small-scale

0.581

High

609882

TM219
Insulin-like growth factor-binding protein 3 receptor

1

0

Small-scale

0.561

High

609860

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.561

High

609880

NONO
Non-POU domain-containing octamer-binding protein

1

1

Small-scale

0.561

High

366328

PLMN
Plasminogen

1

2

Small-scale

0.550

High

591216

CD44
CD44 antigen

2

2

Small-scale

0.550

High

224082

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.541

High

375155

RASK
GTPase KRas

1

2

High-throughput

0.541

High

609883

HUNIN
Humanin

1

0

Small-scale

0.537

High

609873

LRP2
Low-density lipoprotein receptor-related protein 2

1

4

High-throughput

0.536

High

169937

AURKA
Aurora kinase A

1

0

High-throughput

0.518

High

609864

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.518

High

609867

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.518

High

609881

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

609887

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.518

High

609893

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.518

High

609894

RA54B
DNA repair and recombination protein RAD54B

1

0

High-throughput

0.518

High

609870

1433G
14-3-3 protein gamma

1

4

High-throughput

0.515

High

609879

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

High-throughput

0.515

High

609889

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.513

High

609891

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

609892

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

609868

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.501

High

609878

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

18

Small-scale

0.501

High

609890

PAPP2
Pappalysin-2

1

5

Small-scale

0.501

High

362734

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.500

High

609874

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.494

High

603153

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.493

High

609885

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

609886

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

331710

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.489

High

609875

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

1

High-throughput

0.489

High

400244

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

437085

K2C8
Keratin, type II cytoskeletal 8

1

1

Small-scale

0.479

High

464796

SP1
Transcription factor Sp1

1

3

Small-scale

0.479

High

475742

K2C7
Keratin, type II cytoskeletal 7

1

2

Small-scale

0.479

High

601551

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

Small-scale

0.479

High

606184

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.479

High

609861

HNF1A
Hepatocyte nuclear factor 1-alpha

1

1

Small-scale

0.479

High

609863

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

Small-scale

0.479

High

609865

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

15

Small-scale

0.479

High

609869

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.479

High

371107

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

413150

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

426441

HMGN2
Non-histone chromosomal protein HMG-17

1

0

Small-scale

0.458

High

609862

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

Small-scale

0.458

High

609871

H4
Histone H4

1

0

Small-scale

0.458

High

609888

H2A1H
Histone H2A type 1-H

1

0

Small-scale

0.458

High

465398

IGF1R
Insulin-like growth factor 1 receptor

1

5

Small-scale

0.445

High

609872

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.445

High

609884

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

2

Small-scale

0.445

High

609876

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.282

High

609877

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.279

Low

475514

K1C19
Keratin, type I cytoskeletal 19

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025