Interactor 1: IL12B (P29460)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Gene: IL12B

Interactor 2: I12R1 (P42701)
Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)
Gene: IL12RB1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 7911493, 8943050
Identification Methods competition binding
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IL12p40_C~fn3
Common GO terms GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002230 - positive regulation of defense response to virus by host
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0004896 - cytokine receptor activity
GO:0009897 - external side of plasma membrane
and 10 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 328
Hs

1 662
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024