HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: NU153 (P49790)
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Gene: NUP153

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2843 Hs			1 1475
+	Hs
		668531 APC_HUMAN (1-2843): 0: 1286: 100.00		RBP2_HUMAN (45-1341): 1.6e-132: 457: 16.25
+	Hs
		668689 APC_HUMAN (1-2843): 0: 1286: 100.00		RNF31_HUMAN (545-922): 1.78e-45: 181: 15.72
+	Hs
		668690 APC_HUMAN (1-2843): 0: 1286: 100.00		P121A_HUMAN (136-1245): 4.05e-34: 145: 9.26
+	Hs
		668520 APC_HUMAN (1-2843): 0: 1286: 100.00		NU214_HUMAN (69-1466): 3e-30: 133: 10.99
+	Hs
		668538 APC_HUMAN (1-2843): 0: 1286: 100.00		NUP98_HUMAN (907-1474): 7.52e-29: 128: 12.31
+	Hs
		668743 APC_HUMAN (1-2843): 0: 1286: 100.00		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Dm
		1468340 Q9VAS9_DROME (215-2432): 5.58e-158: 550: 19.48		TRBID_DROME (654-921): 1.56e-20: 100: 16.23
+	Dm
		1475920 Q9Y1T2_DROME (327-1450): 1.9e-166: 547: 26.33		TRBID_DROME (654-921): 1.56e-20: 100: 16.23
+	Hs
		1403962 MUC4_HUMAN (730-2841): 1.62e-72: 274: 11.30		MUC4_HUMAN (501-1471): 4.88e-24: 113: 9.46
+	Hs
		274254 ANR17_HUMAN (1869-2843): 7.16e-68: 258: 14.65		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Hs
		1389426 SRRM2_HUMAN (710-2256): 1.43e-21: 105: 9.26		RNF31_HUMAN (545-922): 1.78e-45: 181: 15.72
+	Dm
		1490102 FUTSC_DROME (713-2829): 8.21e-45: 182: 9.87		FUTSC_DROME (35-1292): 9.95e-15: 82.6: 9.91
+	Hs
		1361930 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Hs
		334324 TACC2_HUMAN (817-2843): 1.02e-30: 136: 7.20		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Hs
		698384 MAP4_HUMAN (2038-2724): 6.77e-30: 133: 15.35		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Hs
		1129588 MDC1_HUMAN (1994-2830): 2.42e-23: 111: 11.16		MDC1_HUMAN (282-1077): 9.97e-23: 108: 9.57
+	Hs
		1129637 MDC1_HUMAN (1994-2830): 2.42e-23: 111: 11.16		MICA3_HUMAN (69-642): 6.15e-22: 106: 13.61
+	Hs
		1129772 MDC1_HUMAN (1994-2830): 2.42e-23: 111: 11.16		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Hs
		1459335 SRRM2_HUMAN (710-2256): 1.43e-21: 105: 9.26		ZRAN1_HUMAN (589-796): 2.08e-21: 103: 16.89
+	Ce
		145072 UNC89_CAEEL (837-2156): 4.53e-24: 114: 12.70		O17566_CAEEL (108-580): 2e-14: 81: 11.02