HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding GO:0065003 - protein-containing complex assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2843 Hs			1 337
+	Mm
		1281993 Q8BNP7_MOUSE (1-1058): 0: 1471: 95.09		SCRIB_MOUSE (4-319): 4.86e-15: 78.4: 13.72
+	Hs
		668697 APC_HUMAN (1-2843): 0: 1286: 100.00		MAGI1_HUMAN (2-208): 3.08e-17: 85: 21.05
+	Hs
		668574 APC_HUMAN (1-2843): 0: 1286: 100.00		DLG1_HUMAN (87-234): 5.04e-14: 75: 17.42
+	Hs
		668587 APC_HUMAN (1-2843): 0: 1286: 100.00		SCRIB_HUMAN (4-116): 2.41e-13: 73.1: 23.20
+	Hs
		668572 APC_HUMAN (1-2843): 0: 1286: 100.00		PTN13_HUMAN (89-239): 4.3e-12: 69.2: 21.05
+	Hs
		668681 APC_HUMAN (1-2843): 0: 1286: 100.00		DLG3_HUMAN (89-220): 1.39e-10: 64.6: 17.99
+	Hs
		668731 APC_HUMAN (1-2843): 0: 1286: 100.00		LIN7C_HUMAN (9-87): 8.54e-09: 56.6: 40.74
+	Mm
		1222693 APC_MOUSE (1-2843): 0: 1188: 89.93		DLG4_MOUSE (106-233): 2.51e-15: 78.8: 21.48
+	Rn
		723868 APC_RAT (1-2843): 0: 1188: 89.71		DLG4_RAT (106-233): 2.44e-15: 78.8: 21.48
+	Rn
		1000465 APC_RAT (1-2843): 0: 1188: 89.71		DLG1_RAT (81-232): 2.33e-14: 76.1: 15.57
+	Ce
		111234 APR1_CAEEL (274-1464): 4.78e-114: 396: 17.01		DLG1_CAEEL (4-159): 4.37e-25: 108: 19.11
+	Hs
		698347 MAP4_HUMAN (2038-2724): 6.77e-30: 133: 15.35		SNX27_HUMAN (149-228): 1.9e-09: 60.8: 38.71
+	Rn
		761329 MAP1A_RAT (869-2843): 3.71e-20: 101: 8.37		DLG2_RAT (84-232): 1.95e-15: 79.2: 20.51
+	Rn
		723859 MAP1A_RAT (869-2843): 3.71e-20: 101: 8.37		DLG4_RAT (106-233): 2.44e-15: 78.8: 21.48
+	Hs
		1008620 MAP1A_HUMAN (751-2381): 8.05e-20: 100: 8.02		DLG2_HUMAN (84-232): 1.96e-15: 79.2: 20.51
+	Hs
		1006043 MAP1A_HUMAN (751-2381): 8.05e-20: 100: 8.02		DLG4_HUMAN (106-233): 2.6e-15: 78.8: 21.48
+	Rn
		761326 MAP1A_RAT (869-2843): 3.71e-20: 101: 8.37		DLG1_RAT (81-232): 2.33e-14: 76.1: 15.57
+	Hs
		1008611 MAP1A_HUMAN (751-2381): 8.05e-20: 100: 8.02		DLG1_HUMAN (87-234): 5.04e-14: 75: 17.42
+	Mm
		1223763 MAP1A_MOUSE (894-2843): 2.36e-18: 95.4: 8.29		DLG4_MOUSE (106-233): 2.51e-15: 78.8: 21.48
+	Mm
		1223643 ANK2_MOUSE (1984-2826): 8.33e-15: 83.7: 11.72		DLG4_MOUSE (106-233): 2.51e-15: 78.8: 21.48