HitPredict

Interactor 1: MPIP3 (P30307)
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
Gene: CDC25C

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15791647, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 248
+	Hs
		673560 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		673562 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Xl
		223343 MPIP2_XENLA (1-469): 0: 569: 42.99		O57468_XENLA (2-246): 5.73e-145: 407: 60.00
+	Hs
		646657 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Rn
		89019 D4ADT2_RAT (1-473): 0: 546: 60.55		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Hs
		673545 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Mm
		823143 MPIP3_MOUSE (1-473): 0: 541: 59.24		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Hs
		673559 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		673571 MPIP3_HUMAN (1-473): 0: 661: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		673366 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Rn
		823141 MPIP2_RAT (112-468): 2.07e-143: 424: 38.80		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Hs
		673381 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		673382 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646655 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		646656 MPIP2_HUMAN (121-468): 2.83e-140: 416: 40.11		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Mm
		673543 MPIP2_MOUSE (62-468): 5.73e-143: 423: 35.92		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Hs
		673365 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		673452 MPIP2_HUMAN (121-468): 2.83e-140: 416: 40.11		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		673380 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		673390 MPIP1_HUMAN (95-469): 2.75e-141: 417: 37.95		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20