HitPredict

Interactor 1: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Interactor 2: MNX1 (P50219)
Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)
Gene: MNX1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 401
+	Hs
		213306 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		MNX1_HUMAN (1-401): 1.53e-37: 142: 100.00
+	Hs
		446885 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		HXC4_HUMAN (155-342): 6.76e-36: 134: 28.95
+	Dm
		185813 UBX_DROME (65-265): 4.1e-33: 128: 23.83		PAX6_DROME (21-399): 5.13e-37: 145: 17.15
+	Hs
		211808 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		MNX1_HUMAN (1-401): 1.53e-37: 142: 100.00
+	Dm
		367190 UBX_DROME (65-265): 4.1e-33: 128: 23.83		ANTP_DROME (85-311): 3.23e-36: 137: 27.83
+	Hs
		679132 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		ZFHX4_HUMAN (178-311): 9.8e-10: 62.8: 18.66
+	Dm
		1001370 Q0IGU0_DROME (19-269): 1.19e-34: 132: 20.72		Q0IGU0_DROME (8-314): 5.76e-29: 118: 15.31
+	Dm
		950014 Q7KS72_DROME (117-320): 9.15e-34: 128: 49.52		UBX_DROME (87-302): 1.23e-29: 120: 26.15
+	Dm
		950100 UBX_DROME (65-265): 4.1e-33: 128: 23.83		Q9W1H7_DROME (223-342): 5.45e-31: 119: 29.17
+	Dm
		950110 UBX_DROME (65-265): 4.1e-33: 128: 23.83		Q9XZU0_DROME (233-401): 2.98e-29: 118: 23.73
+	Hs
		174008 SHOX_HUMAN (185-299): 6.57e-34: 127: 25.22		SHOX_HUMAN (230-303): 5.23e-30: 118: 36.49
+	Mm
		446926 HXA1_MOUSE (25-275): 1.43e-32: 125: 23.51		HXA1_MOUSE (18-315): 2.5e-30: 120: 22.37
+	Mm
		192284 ALX4_MOUSE (29-328): 9.59e-32: 124: 17.93		HXA11_MOUSE (18-305): 9.38e-29: 116: 17.41
+	Dm
		950087 UBX_DROME (65-265): 4.1e-33: 128: 23.83		Q9VSC2_DROME (219-311): 3.53e-26: 112: 69.89
+	Hs
		447232 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		MEOX2_HUMAN (234-307): 4.02e-14: 74.3: 54.05
+	Hs
		447257 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		Q6FHY5_HUMAN (234-307): 3.98e-14: 74.3: 54.05
+	Dm
		428860 UBX_DROME (65-265): 4.1e-33: 128: 23.83		DFD_DROME (242-301): 2.24e-14: 76.6: 58.33
+	Hs
		211902 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		ZFHX4_HUMAN (178-311): 9.8e-10: 62.8: 18.66