HitPredict

Interactor 1: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 397 Hs			1 448
+	Hs
		243385 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		681419 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		681421 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	At
		187511 DNAJ3_ARATH (2-396): 4.99e-130: 382: 48.67		CIPKB_ARATH (155-446): 1.12e-125: 373: 22.01
+	Hs
		243384 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		681350 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		243371 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Dm
		1097540 Q9VFV9_DROME (1-397): 1.49e-137: 400: 58.77		DSOR1_DROME (115-446): 2.93e-106: 322: 37.12
+	Hs
		636252 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		681362 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		243318 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		243329 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Sc
		633044 MAS5_YEAST (1-396): 8.35e-140: 406: 45.37		MKK2_YEAST (172-420): 3.93e-60: 206: 41.89
+	Hs
		734993 DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		636259 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Hs
		153086 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		MP2K7_HUMAN (160-431): 1.36e-48: 173: 37.41
+	Sc
		628938 SCJ1_YEAST (7-330): 1.4e-50: 176: 36.42		MKK2_YEAST (172-420): 3.93e-60: 206: 41.89
+	Hs
		805480 DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09