HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12750378
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 840
+	Hs
		408567 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		116975 SGK1_HUMAN (104-478): 5.29e-146: 426: 44.97		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		568562 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320923 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		1267772 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		850687 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		HS105_HUMAN (1-840): 0: 938: 62.95
+	Sc
		520590 YPK1_YEAST (145-445): 2.15e-96: 306: 49.83		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61
+	Hs
		503528 AKT1_HUMAN (1-480): 0: 586: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564016 AKT1_HUMAN (1-480): 0: 586: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		503390 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503922 KPCE_HUMAN (53-474): 3.43e-146: 437: 39.77		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		504896 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		554912 KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53		HS71A_MOUSE (571-686): 1e-17: 89.7: 23.08
+	Hs
		564201 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		503719 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503600 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564041 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		564026 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		504119 KS6A1_HUMAN (85-407): 6.15e-92: 296: 26.39		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564080 KS6A1_HUMAN (85-407): 6.15e-92: 296: 26.39		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86