HitPredict

Interactor 1: PSA4 (P25789)
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3)
Gene: PSMA4

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31839598, 34535262
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 256
+	Hs
		114595 H0YKT8_HUMAN (25-205): 1.08e-132: 374: 100.00		PSA6_HUMAN (2-243): 1.55e-91: 272: 29.27
+	Hs
		114584 H0YKT8_HUMAN (25-205): 1.08e-132: 374: 100.00		PSA5_HUMAN (3-240): 2.24e-91: 271: 36.74
+	Hs
		114581 H0YKT8_HUMAN (25-205): 1.08e-132: 374: 100.00		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		165263 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA7_HUMAN (5-238): 2.03e-101: 297: 82.91
+	Hs
		165303 PSA6_HUMAN (2-244): 3.53e-92: 273: 31.84		PSA7_HUMAN (5-238): 2.03e-101: 297: 82.91
+	Hs
		681610 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA6_HUMAN (2-243): 1.55e-91: 272: 29.27
+	Hs
		681576 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA5_HUMAN (3-240): 2.24e-91: 271: 36.74
+	Ce
		1376826 PSA4_CAEEL (1-237): 1.32e-95: 282: 67.09		PSA7_CAEEL (3-240): 1.6e-93: 277: 57.26
+	Hs
		680771 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		681570 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA4_HUMAN (1-237): 2.55e-89: 266: 34.84
+	Dm
		611462 PSA4_DROME (1-242): 1.03e-92: 275: 72.25		PSA71_DROME (1-237): 1.72e-94: 279: 69.20
+	Sp
		1068360 PSA3_SCHPO (1-247): 3.63e-95: 281: 52.21		PSA4_SCHPO (3-255): 6.95e-91: 270: 53.33
+	Dm
		611502 PSA4_DROME (1-242): 1.03e-92: 275: 72.25		PSA5_DROME (3-241): 9.26e-92: 272: 35.89
+	Hs
		700596 PSA6_HUMAN (2-244): 3.53e-92: 273: 31.84		PSA5_HUMAN (3-240): 2.24e-91: 271: 36.74
+	Hs
		680830 PSA6_HUMAN (2-244): 3.53e-92: 273: 31.84		PSA1_HUMAN (3-249): 1.11e-89: 267: 31.08
+	Hs
		114582 H0YKT8_HUMAN (25-205): 1.08e-132: 374: 100.00		PSA2_HUMAN (1-240): 6.61e-46: 155: 39.51
+	Hs
		681102 PSA4_HUMAN (1-237): 2.21e-98: 290: 100.00		PSA2_HUMAN (1-240): 6.61e-46: 155: 39.51
+	Dm
		611466 PSA4_DROME (1-242): 1.03e-92: 275: 72.25		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Hs
		681139 PSA6_HUMAN (2-244): 3.53e-92: 273: 31.84		PSA2_HUMAN (1-240): 6.61e-46: 155: 39.51