Protein: DDI2
Protein DDI1 homolog 2 (EC 3.4.23.-)

Gene: DDI2
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q5TDH0

Gene Ontology (top 5):
GO:0004190 - aspartic-type endopeptidase activity
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005829 - cytosol
GO:0010498 - proteasomal protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508111

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

20

Small-scale

0.899

High

931670

RD23B
UV excision repair protein RAD23 homolog B

4

19

High-throughput

0.892

High

1216203

NRIP3
Nuclear receptor-interacting protein 3

2

13

High-throughput

0.811

High

138158

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

20

Small-scale

0.754

High

241942

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

968950

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.754

High

1216209

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

7

Small-scale

0.754

High

1216180

DDI1
Protein DDI1 homolog 1

1

19

High-throughput

0.691

High

543219

UBL4A
Ubiquitin-like protein 4A

1

20

High-throughput

0.665

High

1216185

H2B1H
Histone H2B type 1-H

1

5

High-throughput

0.665

High

1216191

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

3

High-throughput

0.665

High

1050446

UBE3A
Ubiquitin-protein ligase E3A

1

18

Small-scale

0.647

High

216456

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

1

High-throughput

0.628

High

1216186

RN166
E3 ubiquitin-protein ligase RNF166

1

17

High-throughput

0.618

High

610370

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

778703

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.618

High

830892

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

851346

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.618

High

856729

BAG6
Large proline-rich protein BAG6

1

18

High-throughput

0.618

High

906538

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

19

High-throughput

0.618

High

929968

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

High-throughput

0.618

High

933662

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

16

High-throughput

0.618

High

942677

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.618

High

968729

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.618

High

975428

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.618

High

1098025

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

19

High-throughput

0.618

High

1136535

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

16

High-throughput

0.618

High

1156453

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

7

High-throughput

0.618

High

1216170

DDI2
Protein DDI1 homolog 2

1

18

High-throughput

0.618

High

1216172

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.618

High

1216184

H2A1C
Histone H2A type 1-C

1

3

High-throughput

0.618

High

1216196

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

19

High-throughput

0.618

High

1216204

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.618

High

1216205

UBQL2
Ubiquilin-2

1

18

High-throughput

0.618

High

1095503

NR1H3
Oxysterols receptor LXR-alpha

2

10

High-throughput

0.611

High

1216183

RDH5
Retinol dehydrogenase 5

3

1

High-throughput

0.609

High

1210456

HP1B3
Heterochromatin protein 1-binding protein 3

2

0

High-throughput

0.602

High

681179

PSA2
Proteasome subunit alpha type-2

2

20

Small-scale

0.584

High

701168

PSB5
Proteasome subunit beta type-5

2

20

Small-scale

0.584

High

931541

RD23A
UV excision repair protein RAD23 homolog A

1

19

High-throughput

0.575

High

1216181

ZDHC1
Palmitoyltransferase ZDHHC1

2

6

High-throughput

0.574

High

1216187

PAUF
Pancreatic adenocarcinoma up-regulated factor

2

6

High-throughput

0.574

High

1147530

UBE3C
Ubiquitin-protein ligase E3C

1

14

High-throughput

0.553

High

1216175

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

1137342

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.536

High

570450

GFAP
Glial fibrillary acidic protein

1

3

High-throughput

0.515

High

927345

ATX1
Ataxin-1

1

5

High-throughput

0.515

High

1096038

TADBP
TAR DNA-binding protein 43

1

10

High-throughput

0.515

High

1216176

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1146376

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.493

High

388781

C1QC
Complement C1q subcomponent subunit C

1

11

High-throughput

0.489

High

1216174

LDH6A
L-lactate dehydrogenase A-like 6A

1

2

High-throughput

0.489

High

1216198

ZN577
Zinc finger protein 577

1

4

High-throughput

0.489

High

1216199

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

1

2

High-throughput

0.489

High

1216202

MAGF1
Melanoma-associated antigen F1

1

2

High-throughput

0.489

High

127993

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

20

High-throughput

0.479

High

128254

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

16

High-throughput

0.479

High

165352

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.479

High

209581

SERA
D-3-phosphoglycerate dehydrogenase

1

2

High-throughput

0.479

High

210972

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

8

High-throughput

0.479

High

215310

TXNL1
Thioredoxin-like protein 1

1

6

High-throughput

0.479

High

295511

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

5

High-throughput

0.479

High

347751

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

413996

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

461583

HS90A
Heat shock protein HSP 90-alpha

1

6

High-throughput

0.479

High

468479

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.479

High

528273

THIO
Thioredoxin

1

6

High-throughput

0.479

High

532653

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

565933

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

633711

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.479

High

680906

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.479

High

681405

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.479

High

681663

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.479

High

700659

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.479

High

700905

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.479

High

701042

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.479

High

821400

TCPZ
T-complex protein 1 subunit zeta

1

7

High-throughput

0.479

High

854668

RAGP1
Ran GTPase-activating protein 1

1

3

High-throughput

0.479

High

874166

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

8

High-throughput

0.479

High

876005

TCPE
T-complex protein 1 subunit epsilon

1

8

High-throughput

0.479

High

881201

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

881965

TCPG
T-complex protein 1 subunit gamma

1

8

High-throughput

0.479

High

887547

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.479

High

887673

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.479

High

899076

TCPQ
T-complex protein 1 subunit theta

1

11

High-throughput

0.479

High

899428

TCPD
T-complex protein 1 subunit delta

1

7

High-throughput

0.479

High

954701

SEM1
26S proteasome complex subunit SEM1

1

5

Small-scale

0.479

High

954829

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.479

High

996198

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

1007066

TCPB
T-complex protein 1 subunit beta

1

9

High-throughput

0.479

High

1216171

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

High-throughput

0.479

High

1216195

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.479

High

1216197

TCPH
T-complex protein 1 subunit eta

1

9

High-throughput

0.479

High

1216207

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

11

High-throughput

0.479

High

1216208

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

849356

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

992592

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1216182

ZN480
Zinc finger protein 480

1

1

High-throughput

0.445

High

341593

EYA4
Protein phosphatase EYA4

1

8

High-throughput

0.437

High

913846

ZN138
Zinc finger protein 138

1

7

High-throughput

0.407

High

1068871

ZN763
Zinc finger protein 763

1

5

High-throughput

0.407

High

1216177

ZN695
Zinc finger protein 695

1

1

High-throughput

0.407

High

1216190

ZN419
Zinc finger protein 419

1

1

High-throughput

0.407

High

1216193

ZN578
Zinc finger protein 578

1

1

High-throughput

0.407

High

1216194

ZIM3
Zinc finger imprinted 3

1

3

High-throughput

0.407

High

1216206

ZN222
Zinc finger protein 222

1

2

High-throughput

0.407

High

1216189

CPNE2
Copine-2

3

0

High-throughput

0.345

High

1187630

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

1187836

FX4L6
Forkhead box protein D4-like 6

1

0

High-throughput

0.279

Low

1216178

CPXCR
CPX chromosomal region candidate gene 1 protein

1

0

High-throughput

0.279

Low

1216188

ELMD3
ELMO domain-containing protein 3

1

0

High-throughput

0.279

Low

1216192

FA81B
Protein FAM81B

1

0

High-throughput

0.279

Low

1216201

CG069
Putative uncharacterized protein PKD1L1-AS1

1

0

High-throughput

0.279

Low

635154

CP2B6
Cytochrome P450 2B6

1

0

High-throughput

0.269

Low

1187870

MOGT2
2-acylglycerol O-acyltransferase 2

1

0

High-throughput

0.269

Low

168861

PLD2
Phospholipase D2

1

0

High-throughput

0.249

Low

601939

ZNF7
Zinc finger protein 7

1

0

High-throughput

0.232

Low

1128601

ZN267
Zinc finger protein 267

1

0

High-throughput

0.232

Low

1132511

ZN846
Zinc finger protein 846

1

0

High-throughput

0.232

Low

1216173

ZN549
Zinc finger protein 549

1

0

High-throughput

0.232

Low

1216179

ZN441
Zinc finger protein 441

1

0

High-throughput

0.232

Low

1216200

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025