Protein: DDI1
Protein DDI1 homolog 1 (EC 3.4.23.-)

Gene: DDI1
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q8WTU0

Gene Ontology (top 5):
GO:0004190 - aspartic-type endopeptidase activity
GO:0010498 - proteasomal protein catabolic process
GO:0031647 - regulation of protein stability
GO:0072711 - cellular response to hydroxyurea
GO:0097752 - regulation of DNA stability

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356074

NRIP3
Nuclear receptor-interacting protein 3

4

11

Small-scale

0.895

High

1356065

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

3

6

High-throughput

0.861

High

1356062

DDI1
Protein DDI1 homolog 1

2

18

High-throughput

0.743

High

923391

MK10
Mitogen-activated protein kinase 10

2

4

High-throughput

0.726

High

288472

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

5

High-throughput

0.700

High

1090817

TRAF2
TNF receptor-associated factor 2

2

13

High-throughput

0.700

High

1216180

DDI2
Protein DDI1 homolog 2

1

19

High-throughput

0.691

High

957634

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

7

High-throughput

0.662

High

1356076

KLH42
Kelch-like protein 42

3

8

High-throughput

0.616

High

1280160

PRRT2
Proline-rich transmembrane protein 2

3

2

High-throughput

0.609

High

1336922

PHC3
Polyhomeotic-like protein 3

3

5

High-throughput

0.609

High

633755

PSB1
Proteasome subunit beta type-1

3

20

High-throughput

0.596

High

891261

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.587

High

508332

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.579

High

350487

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

5

High-throughput

0.553

High

1179627

RGPA2
Ral GTPase-activating protein subunit alpha-2

2

1

High-throughput

0.553

High

1356070

TEKT3
Tektin-3

2

1

High-throughput

0.553

High

138245

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

18

High-throughput

0.553

High

610415

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.553

High

778739

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.553

High

851378

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.553

High

906571

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

17

High-throughput

0.553

High

933696

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

15

High-throughput

0.553

High

968767

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.553

High

969001

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.553

High

975468

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.553

High

1098070

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

17

High-throughput

0.553

High

1136560

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

14

High-throughput

0.553

High

1156468

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

7

High-throughput

0.553

High

1356068

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

17

High-throughput

0.553

High

159766

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.494

High

1356078

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

2

High-throughput

0.489

High

647444

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.489

High

1245537

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

1

High-throughput

0.489

High

1356079

NR2E3
Photoreceptor-specific nuclear receptor

1

10

High-throughput

0.470

High

167333

KLF11
Krueppel-like factor 11

1

13

High-throughput

0.470

High

1356071

RTF2
Replication termination factor 2

1

0

Small-scale

0.458

High

128026

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

20

High-throughput

0.437

High

128279

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

14

High-throughput

0.437

High

165383

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.437

High

181646

CETN3
Centrin-3

1

1

Small-scale

0.437

High

211002

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

7

High-throughput

0.437

High

680965

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.437

High

681203

PSA2
Proteasome subunit alpha type-2

1

20

High-throughput

0.437

High

681460

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.437

High

681690

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.437

High

700696

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.437

High

700933

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.437

High

701062

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.437

High

701197

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.437

High

887572

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.437

High

887701

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.437

High

954867

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.437

High

1356067

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.437

High

1356077

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

10

High-throughput

0.437

High

124628

EYA2
Protein phosphatase EYA2

1

8

High-throughput

0.417

High

1053705

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

High-throughput

0.417

High

1356075

CCL28
C-C motif chemokine 28

5

0

High-throughput

0.375

High

1356063

CYGB
Cytoglobin

3

0

High-throughput

0.352

High

1356064

RSCA1
Regulatory solute carrier protein family 1 member 1

3

0

High-throughput

0.347

High

1356073

SFXN1
Sideroflexin-1

3

0

High-throughput

0.342

High

628310

SDHL
L-serine dehydratase/L-threonine deaminase

2

0

High-throughput

0.316

High

1256962

FBX50
F-box only protein 50

2

0

High-throughput

0.316

High

1356066

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1356069

RPP25
Ribonuclease P protein subunit p25

2

0

High-throughput

0.316

High

942505

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

0

High-throughput

0.279

Low

1130122

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.279

Low

1316025

PRR22
Proline-rich protein 22

1

0

High-throughput

0.279

Low

159993

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.268

Low

1356072

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025