HitPredict

Interactor 1: HNRH1 (P31943)
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]
Gene: HNRNPH1

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	25192599, 29884807, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-RNPHF
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043484 - regulation of RNA splicing
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 449 Hs			1 526
+	Hs
		1031411 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		516620 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		726795 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		516383 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		682916 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		516744 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		1031507 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		516768 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Mm
		193433 HNRH1_MOUSE (1-449): 1.88e-75: 244: 99.78		FUS_MOUSE (1-526): 6.91e-34: 136: 86.72
+	Hs
		682776 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		683027 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		516495 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		516339 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		516689 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05
+	Zm
		8143 A0A1D6ELH4_MAIZE (9-440): 1.34e-72: 242: 13.27		A0A1D6ELH4_MAIZE (273-381): 6.88e-10: 63.5: 23.85
+	Hs
		726678 HNRPF_HUMAN (253-438): 2.66e-11: 67.3: 26.06		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		474021 PAB4L_HUMAN (3-188): 3.01e-38: 144: 15.03		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Sc
		376562 PABP_YEAST (104-380): 3.85e-35: 139: 14.84		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49