HitPredict

Interactor 1: PROF (P25843)
Profilin (Protein chickadee)
Gene: chic

Interactor 2: ENA (Q8T4F7)
Protein enabled
Gene: ENA

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	10220404, 19052223, 31740789
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0007015 - actin filament organization GO:0007300 - ovarian nurse cell to oocyte transport GO:0007391 - dorsal closure GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 126 Dm			1 980
+	Hs
		459505 PROF1_HUMAN (3-126): 1.9e-38: 128: 20.71		VASP_HUMAN (298-634): 2.42e-27: 117: 24.48
+	Mm
		1000464 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		VASP_MOUSE (298-630): 1.23e-29: 124: 24.18
+	Hs
		762429 PROF2_HUMAN (3-126): 1.8e-33: 115: 20.71		VASP_HUMAN (298-634): 2.42e-27: 117: 24.48
+	Hs
		459677 PROF1_HUMAN (3-126): 1.9e-38: 128: 20.71		ENAH_HUMAN (634-979): 2.23e-15: 82.4: 25.28
+	Mm
		986967 PROF1_MOUSE (3-126): 1.31e-36: 123: 19.29		PCLO_MOUSE (363-972): 1.58e-14: 80.9: 10.48
+	Hs
		459791 PROF1_HUMAN (3-126): 1.9e-38: 128: 20.71		EVL_HUMAN (687-978): 2.46e-13: 75.1: 23.08
+	Hs
		762467 PROF2_HUMAN (3-126): 1.8e-33: 115: 20.71		ENAH_HUMAN (634-979): 2.23e-15: 82.4: 25.28
+	Mm
		1440872 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		PCLO_MOUSE (363-972): 1.58e-14: 80.9: 10.48
+	Hs
		762505 PROF2_HUMAN (3-126): 1.8e-33: 115: 20.71		EVL_HUMAN (687-978): 2.46e-13: 75.1: 23.08
+	Mm
		986949 PROF1_MOUSE (3-126): 1.31e-36: 123: 19.29		ENAH_MOUSE (515-979): 3.68e-09: 62.8: 19.00
+	Mm
		1041729 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		ENAH_MOUSE (515-979): 3.68e-09: 62.8: 19.00