HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 36931259, 24255178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 986
+	Hs
		909883 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Mm
		926797 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		ARHG2_MOUSE (1-986): 0: 716: 88.55
+	Hs
		909491 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Hs
		683302 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Mm
		910228 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Mm
		926776 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Hs
		909803 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Hs
		683534 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Mm
		926817 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		ARHGI_MOUSE (1-982): 5.64e-125: 414: 28.54
+	Hs
		909921 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		683631 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		909551 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Mm
		926851 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		ARHG6_MOUSE (15-797): 3.96e-98: 328: 11.14
+	Hs
		909501 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		683307 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Mm
		926773 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		RGRF2_MOUSE (44-801): 1.81e-89: 312: 12.66
+	Hs
		910068 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		683745 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		909662 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06
+	Hs
		683428 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06