Protein: ITAV
Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]

Gene: ITAV, ITGAV
Organism: Homo sapiens
Interactions: 164
UniProt ID: P06756

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001570 - vasculogenesis
GO:0001618 - virus receptor activity
GO:0001846 - opsonin binding
GO:0001968 - fibronectin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423993

ITB3
Integrin beta-3

9

20

Small-scale

0.969

High

447975

ITB5
Integrin beta-5

3

20

Small-scale

0.847

High

447983

ITB8
Integrin beta-8

3

20

Small-scale

0.814

High

447976

ITB6
Integrin beta-6

2

20

Small-scale

0.812

High

431656

ITB1
Integrin beta-1

2

20

Small-scale

0.768

High

168361

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.691

High

447989

CEAM8
Cell adhesion molecule CEACAM8

1

7

High-throughput

0.691

High

448077

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

399525

VTNC
Vitronectin

3

5

Small-scale

0.641

High

448066

DPEP2
Dipeptidase 2

3

0

High-throughput

0.638

High

448004

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.628

High

448016

NAAA
N-acylethanolamine-hydrolyzing acid amidase

2

3

High-throughput

0.628

High

448024

SIA4A
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

2

4

High-throughput

0.628

High

448027

PTC1
Protein patched homolog 1

2

5

High-throughput

0.628

High

448047

TMM25
Transmembrane protein 25

2

2

High-throughput

0.628

High

448057

GGH
Gamma-glutamyl hydrolase

2

2

High-throughput

0.628

High

448079

TN13B
Tumor necrosis factor ligand superfamily member 13B

2

1

High-throughput

0.628

High

447994

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

388903

FINC
Fibronectin

2

6

Small-scale

0.611

High

448031

TAZ
Tafazzin

3

3

High-throughput

0.609

High

448037

SUSD4
Sushi domain-containing protein 4

3

3

High-throughput

0.609

High

448064

FUT8
Alpha-(1,6)-fucosyltransferase

2

0

High-throughput

0.602

High

229862

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

2

3

High-throughput

0.601

High

447961

LEG1
Galectin-1

2

20

High-throughput

0.601

High

448078

FBX2
F-box only protein 2

2

11

High-throughput

0.601

High

447998

PAXI
Paxillin

2

10

Small-scale

0.595

High

447959

MMP2
72 kDa type IV collagenase

2

11

Small-scale

0.584

High

447981

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

2

8

Small-scale

0.584

High

447987

EPHA2
Ephrin type-A receptor 2

2

11

Small-scale

0.584

High

448018

FAK1
Focal adhesion kinase 1

2

12

Small-scale

0.584

High

448071

FBX6
F-box only protein 6

2

11

High-throughput

0.584

High

448055

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

4

High-throughput

0.574

High

447984

MK03
Mitogen-activated protein kinase 3

1

3

Small-scale

0.561

High

448052

CA054
Uncharacterized protein C1orf54

2

5

High-throughput

0.549

High

341276

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

351811

BY55
CD160 antigen

1

4

High-throughput

0.536

High

447969

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

447970

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.536

High

447985

CALX
Calnexin

1

10

High-throughput

0.536

High

448021

MFGM
Lactadherin

1

3

High-throughput

0.536

High

448033

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.536

High

448036

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

1

High-throughput

0.536

High

448040

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.536

High

448050

CLC4F
C-type lectin domain family 4 member F

1

5

High-throughput

0.536

High

448058

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

448080

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

2

High-throughput

0.536

High

188784

TMPS2
Transmembrane protease serine 2

1

11

High-throughput

0.515

High

448072

TMPS4
Transmembrane protease serine 4

1

10

High-throughput

0.515

High

447974

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

447991

TGFR2
TGF-beta receptor type-2

1

4

High-throughput

0.515

High

448002

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.515

High

2086

TVA20
T cell receptor alpha variable 20

1

2

High-throughput

0.514

High

214112

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

447963

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.513

High

142045

CCN1
CCN family member 1

1

1

Small-scale

0.501

High

447962

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

447967

COBA1

1

5

Small-scale

0.501

High

447968

CO6A1

1

5

Small-scale

0.501

High

447971

PA2GA
Phospholipase A2, membrane associated

1

1

Small-scale

0.501

High

447979

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

Small-scale

0.501

High

447990

L1CAM
Neural cell adhesion molecule L1

1

1

Small-scale

0.501

High

447992

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

7

Small-scale

0.501

High

447997

CCN3
CCN family member 3

1

1

Small-scale

0.501

High

448020

LG3BP
Galectin-3-binding protein

1

2

Small-scale

0.501

High

439614

INSR
Insulin receptor

1

10

High-throughput

0.500

High

447957

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.500

High

448035

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

0

High-throughput

0.493

High

342485

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.489

High

388598

C1QA
Complement C1q subcomponent subunit A

1

3

High-throughput

0.489

High

447966

PSPC
Surfactant protein C

1

5

High-throughput

0.489

High

448034

DB136
Defensin beta 136

1

1

High-throughput

0.489

High

448053

LCN9
Epididymal-specific lipocalin-9

1

6

High-throughput

0.489

High

448068

CST9L
Cystatin-9-like

1

4

High-throughput

0.489

High

448075

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.489

High

448083

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

5

Small-scale

0.481

High

447964

OSTP
Osteopontin

1

0

Small-scale

0.480

High

126436

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

127247

LEG8
Galectin-8

1

20

Small-scale

0.479

High

154551

PLPP3
Phospholipid phosphatase 3

1

1

Small-scale

0.479

High

173837

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

178666

ANGP2
Angiopoietin-2

1

5

Small-scale

0.479

High

217716

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

268909

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

9

High-throughput

0.479

High

278209

NCOR1
Nuclear receptor corepressor 1

1

5

Small-scale

0.479

High

362602

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.479

High

400128

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

407746

VWF
von Willebrand factor

1

3

Small-scale

0.479

High

410523

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

15

Small-scale

0.479

High

411192

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

447955

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

7

Small-scale

0.479

High

447956

TSP1
Thrombospondin-1

1

2

Small-scale

0.479

High

447958

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

447960

MET
Hepatocyte growth factor receptor

1

5

Small-scale

0.479

High

447965

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

447972

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

447973

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

447977

NUCL
Nucleolin

1

4

Small-scale

0.479

High

447978

PTN
Pleiotrophin

1

1

Small-scale

0.479

High

447980

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

447986

MK01
Mitogen-activated protein kinase 1

1

3

Small-scale

0.479

High

447988

SHC1
SHC-transforming protein 1

1

4

Small-scale

0.479

High

448000

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.479

High

448001

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

448003

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

Small-scale

0.479

High

448007

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

448008

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

448009

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

448010

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

448011

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

448012

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

448014

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

448015

CO4A3
Collagen alpha-3(IV) chain

1

5

Small-scale

0.479

High

448017

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

448023

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

448025

ILK
Scaffold protein ILK

1

2

Small-scale

0.479

High

448026

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

4

Small-scale

0.479

High

448030

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

448038

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

448042

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

448045

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.479

High

448046

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

Small-scale

0.479

High

448048

PLD3
5'-3' exonuclease PLD3

1

3

High-throughput

0.479

High

448056

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

448059

PLD4
5'-3' exonuclease PLD4

1

3

High-throughput

0.479

High

448061

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

448067

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

448069

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

448070

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.479

High

448073

T106B
Transmembrane protein 106B

1

5

High-throughput

0.479

High

448076

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

448082

NCOR2
Nuclear receptor corepressor 2

1

1

Small-scale

0.479

High

447999

SERPH
Serpin H1

1

4

High-throughput

0.470

High

354502

PAK4
Serine/threonine-protein kinase PAK 4

1

0

Small-scale

0.458

High

447982

IL32
Interleukin-32

1

0

Small-scale

0.458

High

447993

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

447995

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

Small-scale

0.458

High

447996

SDF1
Stromal cell-derived factor 1

1

0

Small-scale

0.458

High

448006

MYPR
Myelin proteolipid protein

1

0

Small-scale

0.458

High

448049

CUL9
Cullin-9

1

0

High-throughput

0.458

High

448051

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

448063

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.458

High

97123

E9PNY5
Fc gamma receptor IIIb

1

3

High-throughput

0.445

High

222244

PSCA
Prostate stem cell antigen

1

4

High-throughput

0.445

High

448005

CD81
CD81 antigen

1

20

High-throughput

0.445

High

448019

SLC31
Amino acid transporter heavy chain SLC3A1

1

3

High-throughput

0.445

High

448028

FAK2
Protein-tyrosine kinase 2-beta

1

12

Small-scale

0.445

High

448029

LRC32
Transforming growth factor beta activator LRRC32

1

1

High-throughput

0.445

High

448032

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.445

High

448062

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

105131

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

448013

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

448039

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

448041

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

448074

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

230937

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.426

High

448065

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

170618

CLGN
Calmegin

1

10

High-throughput

0.407

High

448022

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

448054

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.407

High

448044

LYZL2
Lysozyme-like protein 2

2

0

High-throughput

0.328

High

448081

INSL5
Insulin-like peptide INSL5

2

0

High-throughput

0.328

High

448060

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low

378354

IFNB
Interferon beta

1

0

Small-scale

0.261

Low

448043

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025