Protein: PTPRZ
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)

Gene: PTPRZ, PTPRZ1
Organism: Homo sapiens
Interactions: 41
UniProt ID: P23471

Gene Ontology (top 5):
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005178 - integrin binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

659080

CNTN1
Contactin-1

2

12

Small-scale

0.819

High

424011

ITB3
Integrin beta-3

2

10

Small-scale

0.754

High

659072

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

2

19

Small-scale

0.701

High

659093

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.691

High

440373

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.680

High

609578

LEG3
Galectin-3

3

20

High-throughput

0.667

High

522592

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

16

Small-scale

0.647

High

659091

TENR
Tenascin-R

1

19

Small-scale

0.647

High

659085

CYTSA
Cytospin-A

1

2

High-throughput

0.618

High

377968

TNFA
Tumor necrosis factor

1

1

High-throughput

0.618

High

659094

GIT1
ARF GTPase-activating protein GIT1

1

3

Small-scale

0.618

High

480707

LEG1
Galectin-1

2

20

Small-scale

0.611

High

447981

ITAV
Integrin alpha-V

2

8

Small-scale

0.584

High

410625

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

439952

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

659075

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

659086

ANR11
Ankyrin repeat domain-containing protein 11

1

8

High-throughput

0.553

High

659088

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.553

High

105356

APRIO
Alternative prion protein

2

5

High-throughput

0.533

High

481093

HMGB1
High mobility group protein B1

1

1

Small-scale

0.501

High

640570

MK
Midkine

1

4

Small-scale

0.501

High

659087

IL34
Interleukin-34

1

1

Small-scale

0.501

High

659079

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.489

High

585436

VEGFA
Vascular endothelial growth factor A, long form

1

2

Small-scale

0.479

High

636703

PTN
Pleiotrophin

1

4

Small-scale

0.479

High

659073

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

659074

ADDB
Beta-adducin

1

2

High-throughput

0.479

High

659081

CUL3
Cullin-3

1

3

High-throughput

0.479

High

620136

NUCL
Nucleolin

1

0

Small-scale

0.458

High

659083

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

Small-scale

0.458

High

659076

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

659077

WASP
Actin nucleation-promoting factor WAS

1

8

High-throughput

0.445

High

659078

PAXI
Paxillin

1

10

High-throughput

0.445

High

321435

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.437

High

659090

DDX1
ATP-dependent RNA helicase DDX1

1

2

High-throughput

0.437

High

404672

PRIO
Major prion protein

1

0

High-throughput

0.426

High

659092

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.407

High

659089

SELH
Selenoprotein H

1

0

High-throughput

0.279

Low

659084

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

Small-scale

0.261

Low

659082

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025