Protein: PON2
Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)

Gene: PON2
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q15165

Gene Ontology (top 5):
GO:0004064 - arylesterase activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0009636 - response to toxic substance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338452

EGFR
Epidermal growth factor receptor

4

3

High-throughput

0.694

High

1069116

GOLI
E3 ubiquitin-protein ligase RNF130

4

4

High-throughput

0.694

High

299563

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

3

2

High-throughput

0.667

High

411392

INSR
Insulin receptor

3

2

High-throughput

0.667

High

530666

ITA4
Integrin alpha-4

3

1

High-throughput

0.667

High

613250

ITA6
Integrin alpha-6

3

1

High-throughput

0.667

High

1069104

ARSK
Arylsulfatase K

3

1

High-throughput

0.667

High

1069121

SULF2
Extracellular sulfatase Sulf-2

3

1

High-throughput

0.667

High

1069148

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

3

2

High-throughput

0.667

High

1069151

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

2

High-throughput

0.667

High

1069179

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

3

2

High-throughput

0.667

High

1069183

CATF
Cathepsin F

3

2

High-throughput

0.667

High

260233

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

3

0

High-throughput

0.638

High

502125

BIP
Endoplasmic reticulum chaperone BiP

3

0

High-throughput

0.638

High

1069112

LRP11
Low-density lipoprotein receptor-related protein 11

3

0

High-throughput

0.638

High

1069117

TM219
Insulin-like growth factor-binding protein 3 receptor

3

0

High-throughput

0.638

High

1069124

S39AB
Zinc transporter ZIP11

3

0

High-throughput

0.638

High

1069137

SPP2B
Signal peptide peptidase-like 2B

3

0

High-throughput

0.638

High

1069153

LMLN
Leishmanolysin-like peptidase

3

0

High-throughput

0.638

High

1069161

ABCA2
ATP-binding cassette sub-family A member 2

3

0

High-throughput

0.638

High

1069177

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.638

High

1069189

POMT2
Protein O-mannosyl-transferase 2

3

0

High-throughput

0.638

High

1019205

HYAL2
Hyaluronidase-2

3

0

High-throughput

0.634

High

1069142

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

5

High-throughput

0.628

High

1069144

HMR1
Major histocompatibility complex class I-related gene protein

2

2

High-throughput

0.611

High

1069160

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

2

5

High-throughput

0.611

High

1069171

RN167
E3 ubiquitin-protein ligase RNF167

2

4

High-throughput

0.611

High

206906

CHSTA
Carbohydrate sulfotransferase 10

3

3

High-throughput

0.609

High

1069097

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

3

1

High-throughput

0.609

High

1069131

NETO2
Neuropilin and tolloid-like protein 2

3

1

High-throughput

0.609

High

1069133

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

3

5

High-throughput

0.609

High

1069172

CHSTC
Carbohydrate sulfotransferase 12

3

3

High-throughput

0.609

High

1069180

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

3

High-throughput

0.609

High

1069194

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

3

5

High-throughput

0.609

High

1069141

DNS2B
Deoxyribonuclease-2-beta

2

0

High-throughput

0.602

High

1069154

NAR5
Ecto-ADP-ribosyltransferase 5

2

0

High-throughput

0.602

High

1069175

CNNM1
Metal transporter CNNM1

2

0

High-throughput

0.602

High

167922

NPC1
NPC intracellular cholesterol transporter 1

2

0

High-throughput

0.585

High

305304

NXPH4
Neurexophilin-4

2

0

High-throughput

0.585

High

607762

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

2

0

High-throughput

0.585

High

1021794

TP4A2
Protein tyrosine phosphatase type IVA 2

2

0

High-throughput

0.585

High

1069139

SCRB1
Scavenger receptor class B member 1

2

0

High-throughput

0.585

High

1069178

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

2

0

High-throughput

0.585

High

1069196

UST
Uronyl 2-sulfotransferase

2

2

High-throughput

0.574

High

1069114

AMGO1
Amphoterin-induced protein 1

2

5

High-throughput

0.558

High

146346

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

4

High-throughput

0.536

High

354836

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

355031

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

4

High-throughput

0.536

High

410563

CD1A
T-cell surface glycoprotein CD1a

1

3

High-throughput

0.536

High

488230

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

528101

BMP1
Bone morphogenetic protein 1

1

1

High-throughput

0.536

High

570330

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

2

High-throughput

0.536

High

601923

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

3

High-throughput

0.536

High

621368

CMA1
Chymase

1

3

High-throughput

0.536

High

644575

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

4

High-throughput

0.536

High

644676

NKG2C
NKG2-C type II integral membrane protein

1

4

High-throughput

0.536

High

739592

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

5

High-throughput

0.536

High

851140

PRELP
Prolargin

1

1

High-throughput

0.536

High

1014785

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

5

High-throughput

0.536

High

1020125

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

4

High-throughput

0.536

High

1067494

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.536

High

1069143

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

1069145

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

1069149

ASIC4
Acid-sensing ion channel 4

1

5

High-throughput

0.536

High

1069166

KLK15
Kallikrein-15

1

5

High-throughput

0.536

High

1069185

CLC2D
C-type lectin domain family 2 member D

1

3

High-throughput

0.536

High

1069195

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

3

High-throughput

0.536

High

1069197

KLK5
Kallikrein-5

1

4

High-throughput

0.536

High

1069125

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

924587

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.518

High

637253

CATS
Cathepsin S

1

2

High-throughput

0.515

High

61687

CDHR4
Cadherin-related family member 4

1

0

High-throughput

0.513

High

131896

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

173472

RER1
Protein RER1

1

0

High-throughput

0.513

High

217165

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

275006

RENR
Renin receptor

1

0

High-throughput

0.513

High

277174

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.513

High

351382

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.513

High

389462

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

514388

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

532961

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

738214

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.513

High

1022821

STRN3
Striatin-3

1

0

High-throughput

0.513

High

1041617

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1045073

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.513

High

1069105

ALKL2
ALK and LTK ligand 2

1

0

High-throughput

0.513

High

1069118

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1069126

PCD20
Protocadherin-20

1

0

High-throughput

0.513

High

1069159

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.513

High

1069187

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.513

High

1069188

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.513

High

1069190

CAH14
Carbonic anhydrase 14

1

0

High-throughput

0.513

High

180125

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

238040

UD19
UDP-glucuronosyltransferase 1A9

1

1

High-throughput

0.489

High

595531

GRAH
Granzyme H

1

3

High-throughput

0.489

High

1038968

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

High-throughput

0.489

High

1039066

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.489

High

1069099

CAHD1
VWFA and cache domain-containing protein 1

1

2

High-throughput

0.489

High

1069108

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

2

High-throughput

0.489

High

1069132

CHSTE
Carbohydrate sulfotransferase 14

1

3

High-throughput

0.489

High

1069135

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

3

High-throughput

0.489

High

1069165

CHST8
Carbohydrate sulfotransferase 8

1

3

High-throughput

0.489

High

1069192

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

5

High-throughput

0.489

High

177895

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

236304

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.479

High

429045

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

429896

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

546657

B4GT1
Beta-1,4-galactosyltransferase 1

1

1

High-throughput

0.479

High

869948

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

2

High-throughput

0.479

High

1069111

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1069115

CHSS1
Chondroitin sulfate synthase 1

1

3

High-throughput

0.479

High

1069130

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1069138

RN128
E3 ubiquitin-protein ligase RNF128

1

4

High-throughput

0.479

High

1069140

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

4

High-throughput

0.479

High

1069169

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1069174

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1069176

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

205417

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

456871

FURIN
Furin

1

0

High-throughput

0.458

High

594685

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

882308

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

925292

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

1028049

DNJC3
DnaJ homolog subfamily C member 3

1

0

High-throughput

0.458

High

1053563

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

1069134

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1069152

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.458

High

1069163

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1069184

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1069198

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.458

High

657001

5HT2A
5-hydroxytryptamine receptor 2A

1

1

Small-scale

0.457

High

354951

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

3

High-throughput

0.445

High

1069123

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1069136

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

99604

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

1069101

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

1069119

C1QL4
Complement C1q-like protein 4

3

0

High-throughput

0.347

High

1069128

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

3

0

High-throughput

0.347

High

1069129

PGLT1
Protein O-glucosyltransferase 1

3

0

High-throughput

0.347

High

1069150

TXD15
Thioredoxin domain-containing protein 15

3

0

High-throughput

0.347

High

1069164

SIL1
Nucleotide exchange factor SIL1

3

0

High-throughput

0.347

High

654353

CALX
Calnexin

3

0

High-throughput

0.339

High

1058665

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

0

High-throughput

0.318

High

1069103

MOXD1
DBH-like monooxygenase protein 1

2

0

High-throughput

0.318

High

1069122

UBR2
E3 ubiquitin-protein ligase UBR2

2

0

High-throughput

0.318

High

1069157

CDC6
Cell division control protein 6 homolog

2

0

High-throughput

0.318

High

1069167

SMOC1
SPARC-related modular calcium-binding protein 1

2

0

High-throughput

0.318

High

1069186

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

Small-scale

0.318

High

1069173

FBX6
F-box only protein 6

2

0

High-throughput

0.305

High

317254

PCNT
Pericentrin

1

0

High-throughput

0.279

Low

796224

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.279

Low

1069096

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

1069102

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

1069109

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.279

Low

1069113

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

1069120

NNRD
ATP-dependent

1

0

High-throughput

0.279

Low

1069127

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.279

Low

1069146

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

1069155

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.279

Low

1069168

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

1069170

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1069191

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.279

Low

377333

GCR
Glucocorticoid receptor

1

0

High-throughput

0.249

Low

551526

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.249

Low

609877

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.249

Low

779450

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1069098

UVSSA
UV-stimulated scaffold protein A

1

0

Small-scale

0.249

Low

1069100

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1069106

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1069107

PGAP1
GPI inositol-deacylase

1

0

High-throughput

0.249

Low

1069110

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

1069147

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

1069158

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.249

Low

1069162

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.249

Low

1069181

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1069182

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

1069193

RUVB2
RuvB-like 2

1

0

High-throughput

0.249

Low

2100

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

1022499

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.232

Low

1069156

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024