HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	26065575, 30104358
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BAH~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1616 Hs			1 136
+	Hs
		684970 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		684973 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		684949 DNMT1_HUMAN (1-1616): 0: 1711: 100.00		CENPA_HUMAN (9-133): 3.55e-44: 142: 49.24
+	Xl
		1009516 P79922_XENLA (126-1616): 0: 1498: 70.07		H33_XENLA (1-136): 1.86e-61: 186: 93.38
+	Xl
		1009580 P79922_XENLA (126-1616): 0: 1498: 70.07		Q92133_XENLA (1-136): 3.01e-61: 186: 96.32
+	Xl
		1009399 P79922_XENLA (126-1616): 0: 1498: 70.07		H32_XENLA (1-136): 6e-61: 185: 96.32
+	Hs
		998491 PB1_HUMAN (12-1162): 3.52e-179: 584: 15.23		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		1161923 PB1_HUMAN (12-1162): 3.52e-179: 584: 15.23		H31T_HUMAN (1-136): 1.34e-61: 187: 100.00
+	Hs
		1016988 PB1_HUMAN (12-1162): 3.52e-179: 584: 15.23		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		883596 PB1_HUMAN (12-1162): 3.52e-179: 584: 15.23		CENPA_HUMAN (9-133): 3.55e-44: 142: 49.24
+	Nc
		450154 Q3Y3Z1_NEUCR (1040-1604): 3e-121: 418: 22.53		H3_NEUCR (1-135): 1.71e-58: 179: 88.89
+	Hs
		998901 DNM3B_HUMAN (1130-1325): 7e-42: 169: 17.65		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		999016 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Mm
		312421 DNM3A_MOUSE (1128-1326): 4.52e-37: 154: 17.87		H33_MOUSE (1-136): 1.86e-61: 186: 93.38
+	Hs
		1017341 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		998221 ANK2_HUMAN (15-932): 2.95e-29: 130: 9.73		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		1030664 ANK2_HUMAN (15-932): 2.95e-29: 130: 9.73		H32_HUMAN (1-136): 6e-61: 185: 96.32
+	Hs
		883750 DNM3A_HUMAN (1128-1326): 8.76e-37: 153: 17.87		CENPA_HUMAN (9-133): 3.55e-44: 142: 49.24
+	Hs
		998464 WDR87_HUMAN (38-731): 3.93e-14: 80.6: 11.51		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		883582 NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14		CENPA_HUMAN (9-133): 3.55e-44: 142: 49.24