HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: FOXO1 (Q12778)
Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
Gene: FOXO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	24419059, 33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 655
+	Hs
		971452 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		FOXO1_HUMAN (1-655): 6.26e-106: 337: 100.00
+	Hs
		990152 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		FOXO1_HUMAN (1-655): 6.26e-106: 337: 100.00
+	Hs
		219714 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		FOXO3_HUMAN (4-655): 1.04e-89: 294: 39.00
+	Hs
		219693 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		FOXO3_HUMAN (4-655): 1.04e-89: 294: 39.00
+	Hs
		219716 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		FOXO3_HUMAN (4-655): 1.04e-89: 294: 39.00
+	Hs
		219701 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		FOXO3_HUMAN (4-655): 1.04e-89: 294: 39.00
+	Hs
		46405 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		A0A1X9RU27_HUMAN (78-655): 8.68e-62: 217: 31.06
+	Hs
		46406 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		A0A1X9RU27_HUMAN (78-655): 8.68e-62: 217: 31.06
+	Hs
		971401 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		FOXK1_HUMAN (15-550): 2.71e-43: 168: 15.78
+	Hs
		971461 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		FOXC1_HUMAN (120-282): 1.06e-43: 167: 31.33
+	Hs
		690903 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		FOXK1_HUMAN (15-550): 2.71e-43: 168: 15.78
+	Hs
		990094 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		FOXK1_HUMAN (15-550): 2.71e-43: 168: 15.78
+	Hs
		729746 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		FOXK1_HUMAN (15-550): 2.71e-43: 168: 15.78
+	Dm
		1019882 1433E_DROME (2-242): 6.8e-143: 401: 65.02		FOXO_DROME (88-470): 6.93e-40: 156: 32.74
+	Dm
		709553 1433Z_DROME (1-245): 3.69e-141: 397: 77.14		FOXO_DROME (88-470): 6.93e-40: 156: 32.74
+	Hs
		729703 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		FOXA1_HUMAN (31-441): 8.04e-43: 162: 16.47
+	Hs
		971404 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		FOXO4_HUMAN (3-636): 4.29e-37: 147: 32.97
+	Hs
		990096 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		FOXO4_HUMAN (3-636): 4.29e-37: 147: 32.97
+	Hs
		71810 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		FOXO6_HUMAN (535-655): 2.58e-11: 68.3: 29.27
+	Hs
		71811 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		FOXO6_HUMAN (535-655): 2.58e-11: 68.3: 29.27