HitPredict

Interactor 1: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 2214
+	Hs
		170904 CLGN_HUMAN (11-546): 0: 652: 59.85		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		699038 CALX_HUMAN (1-592): 0: 786: 100.00		SORT_HUMAN (60-756): 1.92e-179: 571: 28.88
+	Hs
		170932 CLGN_HUMAN (11-546): 0: 652: 59.85		SORT_HUMAN (60-756): 1.92e-179: 571: 28.88
+	Hs
		376480 CALX_HUMAN (1-592): 0: 786: 100.00		LDLR_HUMAN (1077-1278): 2.78e-29: 129: 34.48
+	Hs
		698587 CALX_HUMAN (1-592): 0: 786: 100.00		VLDLR_HUMAN (1457-1575): 6.52e-21: 102: 28.57
+	Hs
		698604 CALX_HUMAN (1-592): 0: 786: 100.00		LRP1_HUMAN (1155-1311): 3.67e-09: 64.6: 21.82
+	Hs
		170584 CLGN_HUMAN (11-546): 0: 652: 59.85		LRP6_HUMAN (1445-1549): 6.83e-11: 70.1: 36.94
+	Hs
		170578 CLGN_HUMAN (11-546): 0: 652: 59.85		LRP5_HUMAN (1445-1549): 8.72e-11: 69.7: 37.27
+	Hs
		697857 CALR_HUMAN (67-470): 1.2e-141: 418: 38.33		LRP1_HUMAN (1155-1311): 3.67e-09: 64.6: 21.82