HitPredict

Interactor 1: TEAD1 (P28347)
Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
Gene: TEAD1

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	26186194, 28514442, 25796446, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0035329 - hippo signaling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 400
+	Mm
		717014 TEAD1_MOUSE (1-426): 0: 783: 99.30		WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00
+	Mm
		1190842 Q3USK5_MOUSE (16-426): 0: 750: 91.74		WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00
+	Hs
		1150221 TEAD4_HUMAN (1-426): 0: 725: 74.54		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Mm
		717011 TEAD1_MOUSE (1-426): 0: 783: 99.30		YAP1_MOUSE (15-400): 5.46e-100: 307: 41.30
+	Mm
		1223985 TEAD4_MOUSE (1-426): 0: 728: 74.07		WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00
+	Hs
		703107 TEAD1_HUMAN (1-426): 0: 782: 100.00		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Hs
		1405589 TEAD3_HUMAN (12-426): 0: 691: 71.23		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Mm
		999927 TEAD3_MOUSE (1-426): 0: 684: 69.25		WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00
+	Mm
		862602 TEAD4_MOUSE (1-426): 0: 728: 74.07		YAP1_MOUSE (15-400): 5.46e-100: 307: 41.30
+	Hs
		862160 TEAD4_HUMAN (1-426): 0: 725: 74.54		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Hs
		1150252 TEAD2_HUMAN (32-426): 0: 631: 67.07		WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00
+	Hs
		862403 TEAD3_HUMAN (12-426): 0: 691: 71.23		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Mm
		862594 TEAD3_MOUSE (1-426): 0: 684: 69.25		YAP1_MOUSE (15-400): 5.46e-100: 307: 41.30
+	Mm
		871159 TEAD2_MOUSE (28-426): 0: 612: 65.06		WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00
+	Hs
		862161 TEAD2_HUMAN (32-426): 0: 631: 67.07		YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13
+	Mm
		862592 TEAD2_MOUSE (28-426): 0: 612: 65.06		YAP1_MOUSE (15-400): 5.46e-100: 307: 41.30
+	Hs
		861617 TEAD2_HUMAN (32-426): 0: 631: 67.07		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Dm
		717025 SCAL_DROME (2-426): 0: 569: 58.33		YAP1_DROME (17-223): 5.07e-46: 164: 22.80
+	Sc
		613823 TEC1_YEAST (35-251): 1.94e-29: 121: 21.88		RSP5_YEAST (60-356): 4.42e-33: 133: 13.24