Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1
Interactor 2: TEAD4 (Q15561)
Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
Gene: TEAD4
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 31559693, 32537835, 33961781, 25796446, 29091762, 30472188, 33571521, 35149670, 888800001052, 38280479, 26592798, 25751140, 25751139, unassigned3799, 24525233 |
| Identification Methods | affinity chromatography technology, pull down, proximity labelling technology, isothermal titration calorimetry, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis, bio-layer interferometry, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | TEADIR3~YBD |
| Common GO terms | GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0035329 - hippo signaling and 1 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
