Protein: WWTR1
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)

Gene: WWTR1
Organism: Mus musculus
Interactions: 36
UniProt ID: Q9EPK5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001649 - osteoblast differentiation
GO:0001894 - tissue homeostasis
GO:0003015 - heart process
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862609

YAP1
Transcriptional coactivator YAP1

2

18

Small-scale

0.776

High

1424312

WWTR1
WW domain-containing transcription regulator protein 1

1

18

Small-scale

0.665

High

1064951

RUNX2
Runt-related transcription factor 2

2

19

Small-scale

0.584

High

908802

NEK1
Serine/threonine-protein kinase Nek1

1

20

Small-scale

0.561

High

871159

TEAD2
Transcriptional enhancer factor TEF-4

1

19

High-throughput

0.541

High

999927

TEAD3
Transcriptional enhancer factor TEF-5

1

19

High-throughput

0.541

High

1223985

TEAD4
Transcriptional enhancer factor TEF-3

1

19

High-throughput

0.541

High

1298417

ERCC8
DNA excision repair protein ERCC-8

1

10

High-throughput

0.541

High

1424316

TLE6
Transducin-like enhancer protein 6

1

10

High-throughput

0.541

High

205272

AXIN1
Axin-1

1

5

Small-scale

0.536

High

1363393

CERS2
Ceramide synthase 2

1

3

High-throughput

0.494

High

1424107

CERS5
Ceramide synthase 5

1

3

High-throughput

0.494

High

670159

NECD
Necdin

1

7

Small-scale

0.481

High

717014

TEAD1
Transcriptional enhancer factor TEF-1

1

19

High-throughput

0.481

High

204524

PKD2
Polycystin-2

1

14

Small-scale

0.479

High

313208

LIN7C
Protein lin-7 homolog C

1

20

Small-scale

0.479

High

666054

PAX3
Paired box protein Pax-3

1

4

Small-scale

0.479

High

789701

PPARG
Peroxisome proliferator-activated receptor gamma

1

11

Small-scale

0.479

High

852345

CBP
Histone lysine acetyltransferase CREBBP

1

11

Small-scale

0.479

High

972315

1433E
14-3-3 protein epsilon

1

14

Small-scale

0.479

High

996635

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

1190506

FBW1A
F-box/WD repeat-containing protein 1A

1

16

Small-scale

0.479

High

1210438

FBW1B
F-box/WD repeat-containing protein 11

1

16

Small-scale

0.479

High

1224023

TGFR2
TGF-beta receptor type-2

1

20

High-throughput

0.479

High

1224197

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

1224672

EGLN
Endoglin

1

1

High-throughput

0.479

High

1224969

INADL
InaD-like protein

1

19

Small-scale

0.479

High

1243151

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

6

Small-scale

0.479

High

1297594

LATS1
Serine/threonine-protein kinase LATS1

1

20

Small-scale

0.479

High

1354063

AMOT
Angiomotin

1

20

Small-scale

0.479

High

1424313

PALS1
Protein PALS1

1

20

Small-scale

0.479

High

1424314

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

2

Small-scale

0.479

High

1424315

CUL1
Cullin-1

1

6

Small-scale

0.479

High

1223871

TTF1
Transcription termination factor 1

1

0

Small-scale

0.458

High

1190842

Q3USK5
TEA domain family member 1

1

19

High-throughput

0.457

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025