HitPredict

Interactor 1: S10A2 (P29034)
Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)
Gene: S100A2

Interactor 2: S10A3 (P33764)
Protein S100-A3 (Protein S-100E) (S100 calcium-binding protein A3)
Gene: S100A3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.794

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, mammalian protein protein interaction trap
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0046914 - transition metal ion binding GO:0048306 - calcium-dependent protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 101
+	Hs
		1214472 Q5T7Y6_HUMAN (2-91): 3.16e-40: 131: 52.22		Q5T7Y6_HUMAN (1-90): 1.9e-40: 132: 42.22
+	Mm
		450157 S10A4_MOUSE (2-97): 3.81e-39: 127: 61.46		S10A4_MOUSE (1-98): 3.04e-39: 127: 48.98
+	Hs
		657022 S10A2_HUMAN (1-98): 3.29e-39: 127: 100.00		S10A1_HUMAN (1-90): 1.78e-38: 125: 42.22
+	Hs
		686780 S10A2_HUMAN (1-98): 3.29e-39: 127: 100.00		S10A4_HUMAN (1-98): 1.54e-38: 125: 45.92
+	Mm
		450158 S10A4_MOUSE (2-97): 3.81e-39: 127: 61.46		S10A1_MOUSE (1-90): 1.84e-37: 123: 41.11
+	Hs
		682510 Q5T7Y6_HUMAN (2-91): 3.16e-40: 131: 52.22		S100P_HUMAN (3-91): 5.35e-36: 119: 33.71
+	Hs
		657018 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S10A1_HUMAN (1-90): 1.78e-38: 125: 42.22
+	Hs
		657021 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S10A4_HUMAN (1-98): 1.54e-38: 125: 45.92
+	Hs
		686779 S10A4_HUMAN (2-97): 3.37e-38: 124: 61.46		S10A4_HUMAN (1-98): 1.54e-38: 125: 45.92
+	Hs
		657024 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S10A3_HUMAN (1-101): 5.8e-38: 124: 100.00
+	Hs
		706064 S10A2_HUMAN (1-98): 3.29e-39: 127: 100.00		S10A2_HUMAN (1-97): 1.12e-36: 121: 43.30
+	Hs
		657019 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S100P_HUMAN (3-91): 5.35e-36: 119: 33.71
+	Hs
		407637 Q5T7Y6_HUMAN (2-91): 3.16e-40: 131: 52.22		S100B_HUMAN (3-91): 1.64e-32: 110: 38.20
+	Hs
		657041 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S100Z_HUMAN (1-90): 1.05e-34: 116: 37.78
+	Hs
		407586 S10A2_HUMAN (1-98): 3.29e-39: 127: 100.00		S100B_HUMAN (3-91): 1.64e-32: 110: 38.20
+	Hs
		407580 S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22		S100B_HUMAN (3-91): 1.64e-32: 110: 38.20
+	Hs
		407583 S10A4_HUMAN (2-97): 3.37e-38: 124: 61.46		S100B_HUMAN (3-91): 1.64e-32: 110: 38.20
+	Hs
		445129 S10A4_HUMAN (2-97): 3.37e-38: 124: 61.46		S10A6_HUMAN (1-92): 2.03e-30: 104: 44.57