HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: EFNB2 (P52799)
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Gene: EFNB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0001618 - virus receptor activity GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 333
+	Hs
		914387 EPHA5_HUMAN (11-976): 0: 1115: 51.34		EFNB2_HUMAN (1-333): 0: 517: 100.00
+	Mm
		914521 EPHA4_MOUSE (1-974): 0: 1113: 50.56		EFNB2_MOUSE (4-333): 0: 510: 96.97
+	Dr
		267297 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		EFNB2_DANRE (6-333): 2.05e-158: 448: 65.56
+	Hs
		1022858 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EFNB1_HUMAN (9-333): 2.73e-167: 471: 54.23
+	Dr
		1221071 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		Q90Z31_DANRE (15-333): 4.14e-140: 401: 47.88
+	Hs
		635236 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EFNA1_HUMAN (10-204): 7.84e-74: 228: 22.50
+	Dr
		1221070 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		Q90YC5_DANRE (30-219): 8.74e-64: 203: 25.91
+	Hs
		710133 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EFNA3_HUMAN (22-239): 4.23e-69: 217: 26.52
+	Hs
		914198 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EFNA3_HUMAN (22-239): 4.23e-69: 217: 26.52
+	Dr
		47642 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		A0A8M1Q1X6_DANRE (12-219): 1.14e-58: 189: 23.15
+	Dr
		1009394 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		EFNA2_DANRE (28-177): 4.99e-58: 187: 27.27
+	Dr
		1009395 Q5ZEW1_DANRE (1-974): 0: 1144: 50.76		EFNA5_DANRE (14-166): 4.21e-55: 181: 26.83
+	Hs
		710134 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EFNA4_HUMAN (12-198): 5.41e-58: 187: 24.34
+	Hs
		914264 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EFNA4_HUMAN (12-198): 5.41e-58: 187: 24.34
+	Hs
		710136 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EFNA5_HUMAN (15-204): 1.21e-55: 182: 23.15
+	Hs
		914536 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EFNA5_HUMAN (15-204): 1.21e-55: 182: 23.15
+	Mm
		147437 EPHA7_MOUSE (4-974): 0: 1116: 50.25		EFNA5_MOUSE (15-204): 1.16e-55: 182: 23.65
+	Hs
		914525 EPHA5_HUMAN (11-976): 0: 1115: 51.34		EFNA5_HUMAN (15-204): 1.21e-55: 182: 23.15
+	Hs
		231310 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EFNA2_HUMAN (23-160): 8.02e-51: 169: 27.03
+	Hs
		231304 EPHA4_HUMAN (1-974): 0: 1110: 50.35		EFNA2_HUMAN (23-160): 8.02e-51: 169: 27.03