HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, I-set~fn3, Ig_3~fn3, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 1070
+	Hs
		710503 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROBO2_HUMAN (1-810): 9.04e-106: 363: 15.91
+	Hs
		411419 EPHA2_HUMAN (1-976): 0: 1124: 100.00		NTRK1_HUMAN (555-1061): 3.11e-57: 214: 30.31
+	Hs
		710570 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ALK_HUMAN (695-1067): 1.22e-52: 204: 32.90
+	Hs
		641124 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FGFR2_HUMAN (196-502): 4.79e-48: 187: 16.76
+	Hs
		641143 EPHA4_HUMAN (1-974): 0: 1110: 50.35		FGFR2_HUMAN (196-502): 4.79e-48: 187: 16.76
+	Hs
		650060 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FGFR3_HUMAN (101-408): 2.2e-39: 159: 19.77
+	Hs
		710916 EPHB2_HUMAN (28-973): 0: 1077: 48.29		ALK_HUMAN (695-1067): 1.22e-52: 204: 32.90
+	Hs
		541355 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		650101 EPHA4_HUMAN (1-974): 0: 1110: 50.35		FGFR3_HUMAN (101-408): 2.2e-39: 159: 19.77
+	Hs
		541411 EPHA4_HUMAN (1-974): 0: 1110: 50.35		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		710083 EPHA2_HUMAN (1-976): 0: 1124: 100.00		UFO_HUMAN (21-348): 2.32e-27: 122: 18.80
+	Hs
		710194 EPHA2_HUMAN (1-976): 0: 1124: 100.00		TYRO3_HUMAN (226-606): 1.4e-26: 119: 13.14
+	Hs
		710268 EPHA2_HUMAN (1-976): 0: 1124: 100.00		NTRK2_HUMAN (137-313): 1.03e-17: 90.9: 18.99
+	Hs
		710265 EPHA2_HUMAN (1-976): 0: 1124: 100.00		NTRK3_HUMAN (40-228): 3.85e-16: 85.5: 19.10
+	Hs
		1147330 EPHA7_HUMAN (4-974): 0: 1120: 50.15		NTRK3_HUMAN (40-228): 3.85e-16: 85.5: 19.10
+	Hs
		648428 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FGFR4_HUMAN (2-127): 4.45e-13: 75.8: 17.02
+	Hs
		648517 EPHA7_HUMAN (4-974): 0: 1120: 50.15		FGFR4_HUMAN (2-127): 4.45e-13: 75.8: 17.02
+	Hs
		648471 EPHA4_HUMAN (1-974): 0: 1110: 50.35		FGFR4_HUMAN (2-127): 4.45e-13: 75.8: 17.02
+	Hs
		640326 EPHA1_HUMAN (17-967): 0: 947: 49.28		ALK_HUMAN (695-1067): 1.22e-52: 204: 32.90
+	Hs
		640241 EPHA1_HUMAN (17-967): 0: 947: 49.28		TITIN_HUMAN (599-828): 3.2e-10: 67: 15.25