HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: DLG3 (Q92796)
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)
Gene: DLG3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PK_Tyr_Ser-Thr~SH3_1, PDZ~SAM_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 817
+	Hs
		710208 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Hs
		1091501 EPHA7_HUMAN (4-974): 0: 1120: 50.15		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Hs
		931842 EPHA5_HUMAN (11-976): 0: 1115: 51.34		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Hs
		932062 EPHA4_HUMAN (1-974): 0: 1110: 50.35		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Hs
		710528 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PALS2_HUMAN (271-812): 9.71e-113: 355: 23.85
+	Hs
		710385 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DLG5_HUMAN (61-663): 5.85e-20: 97.9: 15.50
+	Hs
		168639 EPHA2_HUMAN (1-976): 0: 1124: 100.00		CSKP_HUMAN (106-288): 4.34e-16: 85.2: 15.20
+	Hs
		710288 EPHA2_HUMAN (1-976): 0: 1124: 100.00		MPP7_HUMAN (98-226): 1.12e-15: 82.9: 16.28
+	Hs
		168694 EPHA7_HUMAN (4-974): 0: 1120: 50.15		CSKP_HUMAN (106-288): 4.34e-16: 85.2: 15.20
+	Hs
		1147344 EPHA7_HUMAN (4-974): 0: 1120: 50.15		MPP7_HUMAN (98-226): 1.12e-15: 82.9: 16.28
+	Hs
		710361 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PALS1_HUMAN (68-304): 4.08e-14: 78.2: 16.13
+	Hs
		168659 EPHA4_HUMAN (1-974): 0: 1110: 50.35		CSKP_HUMAN (106-288): 4.34e-16: 85.2: 15.20
+	Hs
		720208 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Hs
		463488 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		DLG1_HUMAN (7-817): 0: 607: 61.96
+	Rn
		92830 INSR_RAT (371-873): 1.87e-134: 440: 29.49		MPP2_RAT (270-812): 1.53e-101: 327: 23.94
+	Hs
		650293 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		PALS1_HUMAN (68-304): 4.08e-14: 78.2: 16.13
+	Hs
		650129 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		EM55_HUMAN (92-221): 1.3e-11: 69.8: 17.16
+	Hs
		168616 HCK_HUMAN (591-880): 1.47e-65: 231: 42.12		CSKP_HUMAN (106-288): 4.34e-16: 85.2: 15.20
+	Hs
		168615 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		CSKP_HUMAN (106-288): 4.34e-16: 85.2: 15.20
+	Hs
		463454 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		EM55_HUMAN (92-221): 1.3e-11: 69.8: 17.16