HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PDZ~SAM_1
Common GO terms	GO:0005886 - plasma membrane GO:0070160 - tight junction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 372
+	Hs
		710463 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PAR6G_HUMAN (1-372): 1.48e-130: 380: 54.73
+	Hs
		710511 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PAR6A_HUMAN (1-325): 1.85e-96: 292: 53.37
+	Hs
		168639 EPHA2_HUMAN (1-976): 0: 1124: 100.00		CSKP_HUMAN (71-307): 1.1e-57: 203: 19.61
+	Hs
		168694 EPHA7_HUMAN (4-974): 0: 1120: 50.15		CSKP_HUMAN (71-307): 1.1e-57: 203: 19.61
+	Hs
		168659 EPHA4_HUMAN (1-974): 0: 1110: 50.35		CSKP_HUMAN (71-307): 1.1e-57: 203: 19.61
+	Hs
		710528 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PALS2_HUMAN (68-305): 1.95e-41: 154: 16.67
+	Hs
		710288 EPHA2_HUMAN (1-976): 0: 1124: 100.00		MPP7_HUMAN (71-306): 1.29e-37: 144: 15.25
+	Hs
		710361 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PALS1_HUMAN (82-306): 6.44e-37: 143: 20.00
+	Hs
		932000 EPHB4_HUMAN (14-970): 0: 974: 44.99		PAR6A_HUMAN (1-325): 1.85e-96: 292: 53.37
+	Hs
		1147344 EPHA7_HUMAN (4-974): 0: 1120: 50.15		MPP7_HUMAN (71-306): 1.29e-37: 144: 15.25
+	Rn
		92830 INSR_RAT (371-873): 1.87e-134: 440: 29.49		MPP2_RAT (68-305): 1.04e-37: 144: 15.55
+	Hs
		650293 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		PALS1_HUMAN (82-306): 6.44e-37: 143: 20.00
+	Hs
		650129 FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65		EM55_HUMAN (125-305): 1.92e-33: 131: 18.82
+	Hs
		168616 HCK_HUMAN (591-880): 1.47e-65: 231: 42.12		CSKP_HUMAN (71-307): 1.1e-57: 203: 19.61
+	Hs
		168615 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		CSKP_HUMAN (71-307): 1.1e-57: 203: 19.61
+	Hs
		463806 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		PALS2_HUMAN (68-305): 1.95e-41: 154: 16.67
+	Hs
		463569 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		MPP7_HUMAN (71-306): 1.29e-37: 144: 15.25
+	Hs
		463454 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		EM55_HUMAN (125-305): 1.92e-33: 131: 18.82