Protein: PAR6A
Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)

Gene: PAR6A, PARD6A
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9NPB6

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005634 - nucleus
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

835760

KPCI
Protein kinase C iota type

13

20

Small-scale

0.986

High

1051320

KPCZ
Protein kinase C zeta type

12

20

Small-scale

0.982

High

1353284

PARD3
Partitioning defective 3 homolog

7

20

Small-scale

0.963

High

955634

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.935

High

988734

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.831

High

987962

GRB2
Growth factor receptor-bound protein 2

2

13

High-throughput

0.819

High

1418678

PAR6B
Partitioning defective 6 homolog beta

2

15

High-throughput

0.811

High

1241043

L2GL2
LLGL scribble cell polarity complex component 2

4

8

High-throughput

0.702

High

932000

EPHB4
Ephrin type-B receptor 4

1

14

High-throughput

0.691

High

1115616

ASPP2
Apoptosis-stimulating of p53 protein 2

1

4

High-throughput

0.691

High

1405333

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

11

High-throughput

0.691

High

1446173

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

4

High-throughput

0.691

High

1097118

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

7

Small-scale

0.637

High

1364883

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

11

High-throughput

0.634

High

1146350

L2GL1
Lethal(2) giant larvae protein homolog 1

2

8

High-throughput

0.628

High

601458

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

Small-scale

0.621

High

159874

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.618

High

603368

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.618

High

710511

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

787452

TGFR1
TGF-beta receptor type-1

1

4

Small-scale

0.618

High

1270534

MARK2
Serine/threonine-protein kinase MARK2

1

8

High-throughput

0.618

High

1325315

PALS1
Protein PALS1

1

18

Small-scale

0.618

High

1341101

INADL
InaD-like protein

1

20

Small-scale

0.618

High

1396681

MARK4
MAP/microtubule affinity-regulating kinase 4

1

8

High-throughput

0.618

High

1438977

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

13

Small-scale

0.584

High

1436490

ECT2
Protein ECT2

1

9

Small-scale

0.573

High

1163764

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

20

High-throughput

0.553

High

716634

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

5

High-throughput

0.536

High

907941

PLXA3
Plexin-A3

1

9

High-throughput

0.536

High

923640

TTC3
E3 ubiquitin-protein ligase TTC3

1

7

High-throughput

0.536

High

1049814

1433F
14-3-3 protein eta

1

13

High-throughput

0.536

High

1287289

DPP9
Dipeptidyl peptidase 9

1

1

High-throughput

0.536

High

1394193

LRCH3
DISP complex protein LRCH3

1

7

High-throughput

0.536

High

1435173

RPAP3
RNA polymerase II-associated protein 3

1

5

High-throughput

0.536

High

1446174

SGT1
Protein SGT1 homolog

1

6

High-throughput

0.536

High

749811

CADH5
Cadherin-5

1

2

Small-scale

0.534

High

104042

F5GZI3
Partitioning defective 3 homolog

1

20

High-throughput

0.514

High

928713

PMS2
Mismatch repair endonuclease PMS2

1

0

High-throughput

0.513

High

1104370

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.513

High

1133279

ARI5B
AT-rich interactive domain-containing protein 5B

1

0

High-throughput

0.513

High

1429432

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

1437272

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

1446169

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

0

High-throughput

0.513

High

1446172

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.513

High

1412031

WDR83
WD repeat domain-containing protein 83

1

2

Small-scale

0.504

High

423240

A4
Amyloid-beta precursor protein

1

13

High-throughput

0.501

High

844013

HD
Huntingtin

1

4

Small-scale

0.500

High

1034132

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

0

Small-scale

0.493

High

246148

KIF1B
Kinesin-like protein KIF1B

1

13

High-throughput

0.489

High

359748

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.489

High

1340423

RASF8
Ras association domain-containing protein 8

1

2

High-throughput

0.489

High

791748

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

822874

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

903487

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

2

High-throughput

0.479

High

971126

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

990768

1433Z
14-3-3 protein zeta/delta

1

13

High-throughput

0.479

High

1111438

DGKZ
Diacylglycerol kinase zeta

1

13

Small-scale

0.479

High

1229258

RHG17
Rho GTPase-activating protein 17

1

6

Small-scale

0.479

High

1329887

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1437700

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

13

Small-scale

0.479

High

1446170

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1220947

FBX31
F-box only protein 31

1

0

Small-scale

0.458

High

1247005

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.458

High

1336483

PNMA1
Paraneoplastic antigen Ma1

1

5

High-throughput

0.437

High

75852

B4DDV3
protein acetyllysine N-acetyltransferase

1

3

High-throughput

0.407

High

1438118

Q9HBD4
SMARCA4 isoform 2

1

2

High-throughput

0.407

High

1260538

NOL8
Nucleolar protein 8

1

0

High-throughput

0.279

Low

1398613

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.279

Low

1446171

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025