HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10559276
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 793
+	Hs
		711257 SHC1_HUMAN (1-583): 0: 529: 100.00		MYH10_HUMAN (1-631): 5.25e-22: 104: 9.40
+	Hs
		711256 SHC1_HUMAN (1-583): 0: 529: 100.00		MYH9_HUMAN (10-659): 9.61e-22: 103: 9.76
+	Hs
		711258 SHC1_HUMAN (1-583): 0: 529: 100.00		MYH11_HUMAN (6-537): 3.23e-16: 85.6: 11.09
+	Mm
		1296766 ANS1B_MOUSE (39-361): 8.03e-51: 191: 19.41		ITSN1_MOUSE (241-644): 3.46e-29: 127: 22.77
+	Hs
		1143227 Q96D37_HUMAN (154-578): 1.52e-55: 202: 11.97		PLEC_HUMAN (12-768): 3.36e-22: 105: 12.58
+	Hs
		584543 VAV_HUMAN (154-578): 2.52e-55: 202: 11.97		PLEC_HUMAN (12-768): 3.36e-22: 105: 12.58
+	Hs
		294878 BCAR3_HUMAN (379-583): 6.26e-38: 151: 23.83		MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98
+	Hs
		556946 SHD_HUMAN (328-582): 1.37e-47: 171: 23.02		MYH7_HUMAN (4-602): 5.3e-21: 101: 11.37
+	Hs
		563066 SHD_HUMAN (328-582): 1.37e-47: 171: 23.02		MYH8_HUMAN (3-615): 1.07e-20: 100: 10.59
+	Dm
		118278 NUMB_DROME (117-466): 6.51e-43: 163: 15.86		M9ND00_DROME (260-532): 4.59e-21: 101: 16.85
+	Hs
		587548 NCK1_HUMAN (360-575): 1.56e-41: 155: 18.30		DESP_HUMAN (13-640): 3.04e-22: 105: 14.35
+	Hs
		456090 FES_HUMAN (326-581): 1.81e-37: 150: 21.79		DESP_HUMAN (13-640): 3.04e-22: 105: 14.35
+	Hs
		456106 FES_HUMAN (326-581): 1.81e-37: 150: 21.79		PLEC_HUMAN (12-768): 3.36e-22: 105: 12.58
+	Hs
		699767 P85A_HUMAN (300-581): 8.31e-38: 151: 15.31		ITSN1_HUMAN (5-350): 3.71e-22: 104: 17.43
+	Hs
		136312 P85B_HUMAN (292-581): 8.3e-32: 132: 17.15		MYH10_HUMAN (1-631): 5.25e-22: 104: 9.40
+	Hs
		136311 P85B_HUMAN (292-581): 8.3e-32: 132: 17.15		MYH9_HUMAN (10-659): 9.61e-22: 103: 9.76
+	Hs
		773152 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		MYH10_HUMAN (1-631): 5.25e-22: 104: 9.40
+	Hs
		772723 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		MYH9_HUMAN (10-659): 9.61e-22: 103: 9.76
+	Hs
		776799 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		MYH11_HUMAN (6-537): 3.23e-16: 85.6: 11.09
+	Hs
		987539 GRB2_HUMAN (482-578): 1.66e-15: 77.5: 30.48		MAP1A_HUMAN (212-642): 6.1e-13: 75: 18.04