HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28581483, 31577950
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 183
+	Hs
		320838 HS74L_HUMAN (1-840): 0: 959: 63.21		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		896169 HS105_HUMAN (1-840): 0: 938: 62.95		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Sc
		695097 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		UBC12_YEAST (1-173): 4.43e-45: 148: 43.02
+	Hs
		504528 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90
+	Hs
		503798 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00
+	Hs
		713935 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00