HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	33545068, 14702098
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 440
+	Hs
		1036768 HS105_HUMAN (1-840): 0: 938: 62.95		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1056094 HS105_HUMAN (1-840): 0: 938: 62.95		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Hs
		504032 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		483762 HS71A_HUMAN (571-686): 1.59e-19: 95.5: 23.93		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		504082 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78