HitPredict

Interactor 1: PTN11 (P35235)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
Gene: Ptpn11

Interactor 2: LRB4A (Q64281)
Leukocyte immunoglobulin-like receptor subfamily B member 4A (Mast cell surface glycoprotein Gp49B) (CD antigen CD85k)
Gene: Lilrb4a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.514

Property	Details
Experiments	9973385, 18550825
Identification Methods	unspecified method, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Mm			1 335
+	Hs
		798184 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L3_HUMAN (1-330): 3.19e-77: 241: 27.04
+	Hs
		798139 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L1_HUMAN (1-333): 5.62e-76: 238: 26.50
+	Hs
		986023 PTN11_HUMAN (1-593): 0: 606: 99.49		KI2L4_HUMAN (1-331): 5.91e-72: 229: 24.20
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 606: 99.49		FGFR2_HUMAN (39-319): 6.89e-50: 179: 12.08
+	Mm
		665991 PTN6_MOUSE (6-583): 0: 544: 55.94		LRB4A_MOUSE (1-335): 2.43e-72: 229: 100.00
+	Hs
		685206 PTN11_HUMAN (1-593): 0: 606: 99.49		FCG2B_HUMAN (1-325): 2.53e-46: 161: 14.63
+	Hs
		985972 PTN11_HUMAN (1-593): 0: 606: 99.49		LAIR1_HUMAN (119-323): 3.24e-41: 147: 21.37
+	Mm
		719293 PTN11_MOUSE (1-593): 0: 605: 100.00		LIRB3_MOUSE (10-335): 6.23e-37: 142: 26.49
+	Mm
		719316 PTN11_MOUSE (1-593): 0: 605: 100.00		Q8K4V6_MOUSE (28-319): 6.13e-29: 119: 19.55
+	Hs
		601466 PTN6_HUMAN (6-593): 0: 540: 54.79		FGFR2_HUMAN (39-319): 6.89e-50: 179: 12.08
+	Hs
		252776 PTN6_HUMAN (6-593): 0: 540: 54.79		LIRB3_HUMAN (2-335): 2.09e-45: 165: 27.18
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 606: 99.49		FGFR1_HUMAN (1-249): 1.13e-19: 91.8: 10.04
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 606: 99.49		PTK7_HUMAN (14-256): 1.98e-19: 91.4: 11.60
+	Hs
		798232 PTN11_HUMAN (1-593): 0: 606: 99.49		KI3L1_HUMAN (119-321): 1.81e-16: 81.8: 19.02
+	Mm
		665982 PTN6_MOUSE (6-583): 0: 544: 55.94		LIRB3_MOUSE (10-335): 6.23e-37: 142: 26.49
+	Hs
		532367 PTN11_HUMAN (1-593): 0: 606: 99.49		CEAM1_HUMAN (3-229): 1.21e-11: 67.5: 14.17
+	Mm
		665995 PTN6_MOUSE (6-583): 0: 544: 55.94		LAIR1_MOUSE (16-133): 2.38e-24: 101: 24.79
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 540: 54.79		CD22_HUMAN (20-237): 8.31e-14: 74.4: 15.68
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 544: 55.94		CD22_MOUSE (19-233): 1.26e-10: 64.4: 15.95
+	Hs
		532361 PTN6_HUMAN (6-593): 0: 540: 54.79		CEAM1_HUMAN (3-229): 1.21e-11: 67.5: 14.17