HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: CUL7 (Q14999)
Cullin-7 (CUL-7)
Gene: CUL7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18498745, 29269414
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1242 Hs			1 1698
+	Hs
		64706 RHG32_HUMAN (302-1240): 1.06e-36: 153: 13.08		CUL7_HUMAN (1-1698): 0: 2861: 100.00
+	Hs
		1056833 MDC1_HUMAN (356-1239): 1.69e-20: 100: 10.39		CUL7_HUMAN (1-1698): 0: 2861: 100.00
+	Hs
		944679 MAP1A_HUMAN (253-933): 1.26e-10: 68.4: 9.08		CUL7_HUMAN (1-1698): 0: 2861: 100.00
+	Hs
		1057026 MDC1_HUMAN (356-1239): 1.69e-20: 100: 10.39		APC10_HUMAN (830-969): 1.42e-51: 181: 23.45
+	Mm
		1118155 ANK2_MOUSE (311-1225): 5.86e-27: 122: 11.78		HERC2_MOUSE (838-982): 5.36e-38: 159: 34.48
+	Hs
		319840 MDC1_HUMAN (356-1239): 1.69e-20: 100: 10.39		HERC2_HUMAN (838-982): 1.36e-38: 161: 36.55
+	Dm
		1370265 Q9VLS7_DROME (239-918): 4.03e-13: 76.5: 7.93		HERC2_DROME (356-456): 1.04e-33: 145: 32.69