HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.727

Property	Details
Experiments	15316008, 22974441
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1242 Hs			1 756
+	Rn
		292432 IRS1_RAT (1-1242): 5.19e-133: 440: 87.26		GRB14_RAT (76-617): 1.12e-117: 366: 15.02
+	Hs
		1344702 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		SH2B1_HUMAN (1-756): 8.51e-173: 516: 100.00
+	Hs
		724541 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Mm
		724592 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		SHC1_MOUSE (52-627): 1.88e-100: 323: 17.07
+	Hs
		412057 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		FYN_HUMAN (401-742): 2.99e-74: 252: 13.87
+	Hs
		562631 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		PLCG2_HUMAN (507-753): 4.8e-47: 183: 17.11
+	Hs
		151717 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		SHC1_HUMAN (52-627): 2.87e-100: 322: 17.54
+	Dm
		1178934 IRS1_DROME (6-914): 8.1e-87: 305: 18.00		Q7K137_DROME (83-638): 3.55e-89: 297: 29.55
+	Mm
		724599 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		GRB2_MOUSE (506-648): 1.34e-40: 150: 17.48
+	Hs
		1031729 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Hs
		724527 IRS1_HUMAN (1-1242): 5.63e-152: 491: 100.00		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Mm
		946349 IRS2_MOUSE (13-1192): 6.15e-80: 290: 28.85		GRB10_MOUSE (110-618): 3.47e-84: 281: 11.93
+	Hs
		151706 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		581086 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		151689 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		LCK_HUMAN (435-742): 9.33e-67: 231: 17.13
+	Rn
		724631 IRS1_RAT (1-1242): 5.19e-133: 440: 87.26		GRB2_RAT (517-646): 2.75e-16: 80.5: 18.46
+	Mm
		946348 IRS2_MOUSE (13-1192): 6.15e-80: 290: 28.85		GRB2_MOUSE (506-648): 1.34e-40: 150: 17.48
+	Hs
		151763 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Rn
		94388 F1MAL5_RAT (13-1191): 5.36e-78: 284: 28.84		GRB2_RAT (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		924983 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46