HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 288
+	Hs
		925089 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		726800 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		727057 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		967154 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		727096 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		925008 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		1054480 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		726815 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		967515 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		642763 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		ELAV4_HUMAN (52-261): 1.84e-24: 103: 18.40
+	At
		97485 TAF15_ARATH (281-452): 1.02e-39: 149: 34.30		SUA_ARATH (80-275): 7.98e-15: 76.4: 24.50
+	Mm
		892749 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		CIRBP_MOUSE (120-192): 3.89e-11: 62.4: 57.53
+	Hs
		726810 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		680441 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Mm
		857328 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		TIA1_MOUSE (113-248): 1.05e-17: 84.1: 18.42
+	Hs
		967165 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03