HitPredict

Interactor 1: MKK2 (P32491)
MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)
Gene: MKK2

Interactor 2: GCN1 (P33892)
eIF-2-alpha kinase activator GCN1 (General control non-derepressible protein 1) (Translational activator GCN1)
Gene: GCN1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20489023
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 506 Sc			1 2672
+	Hs
		667956 CDK2_HUMAN (211-487): 5.79e-126: 371: 25.59		GCN1_HUMAN (1-2622): 0: 1447: 25.53
+	Hs
		605764 KAPCA_HUMAN (177-503): 1.04e-123: 367: 21.32		GCN1_HUMAN (1-2622): 0: 1447: 25.53
+	Hs
		162021 MP2K7_HUMAN (212-481): 1.94e-46: 168: 39.72		GCN1_HUMAN (1-2622): 0: 1447: 25.53
+	Hs
		718206 STK24_HUMAN (207-503): 1.57e-107: 329: 33.22		2AAB_HUMAN (1663-2209): 4.77e-57: 212: 14.98
+	Hs
		138810 STK25_HUMAN (211-505): 3.21e-107: 327: 35.12		2AAB_HUMAN (1663-2209): 4.77e-57: 212: 14.98
+	Hs
		718186 STK26_HUMAN (206-504): 4.2e-107: 327: 34.32		2AAB_HUMAN (1663-2209): 4.77e-57: 212: 14.98
+	Hs
		667923 CDK2_HUMAN (211-487): 5.79e-126: 371: 25.59		CAND1_HUMAN (814-1730): 4.02e-35: 149: 10.50
+	Hs
		605739 KAPCA_HUMAN (177-503): 1.04e-123: 367: 21.32		CAND1_HUMAN (814-1730): 4.02e-35: 149: 10.50
+	Hs
		1093140 STK4_HUMAN (195-492): 1.58e-109: 335: 33.00		CAND1_HUMAN (814-1730): 4.02e-35: 149: 10.50
+	Hs
		717693 AKT1_HUMAN (147-501): 1.08e-124: 374: 20.06		2AAA_HUMAN (992-1516): 3.82e-21: 102: 14.54
+	At
		1182742 KIN10_ARATH (213-504): 2.18e-129: 387: 24.92		TOR_ARATH (1923-2324): 4.36e-11: 71.3: 18.55
+	At
		1182199 CIPKG_ARATH (200-489): 2.9e-119: 360: 24.01		2AAA_ARATH (2204-2604): 9.62e-14: 79: 8.90
+	Hs
		718076 STK24_HUMAN (207-503): 1.57e-107: 329: 33.22		2AAA_HUMAN (992-1516): 3.82e-21: 102: 14.54
+	Hs
		138809 STK25_HUMAN (211-505): 3.21e-107: 327: 35.12		2AAA_HUMAN (992-1516): 3.82e-21: 102: 14.54
+	Hs
		718029 STK26_HUMAN (206-504): 4.2e-107: 327: 34.32		2AAA_HUMAN (992-1516): 3.82e-21: 102: 14.54
+	Hs
		164565 STK3_HUMAN (209-503): 3.7e-107: 329: 34.34		TNPO2_HUMAN (2073-2627): 1.92e-09: 65.5: 11.64
+	Hs
		1038317 MP2K1_HUMAN (193-481): 7.81e-55: 190: 37.50		CAND1_HUMAN (814-1730): 4.02e-35: 149: 10.50
+	Hs
		717716 MP2K3_HUMAN (212-497): 2.59e-47: 169: 36.74		2AAA_HUMAN (992-1516): 3.82e-21: 102: 14.54
+	Dm
		263560 O61444_DROME (212-506): 1.02e-45: 167: 38.49		CAND1_DROME (845-2002): 1.81e-18: 95.2: 9.60