HitPredict

Interactor 1: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Interactor 2: STXB2 (Q15833)
Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)
Gene: STXBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin
Common GO terms	GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 593
+	Mm
		204928 STX1A_MOUSE (1-287): 5.22e-78: 240: 65.63		STXB2_MOUSE (1-593): 0: 706: 94.77
+	Rn
		746113 STX1A_RAT (1-287): 7.32e-78: 239: 65.28		STXB2_RAT (1-593): 0: 689: 93.94
+	Rn
		894401 STX2_RAT (1-265): 4.79e-72: 225: 89.51		STXB2_RAT (1-593): 0: 689: 93.94
+	Hs
		746189 STX2_HUMAN (1-288): 5.72e-82: 250: 100.00		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Mm
		147935 STX1B_MOUSE (1-287): 6.05e-81: 247: 64.81		STXB1_MOUSE (1-591): 0: 632: 63.47
+	Rn
		960333 STX1B_RAT (1-287): 6.05e-81: 247: 64.81		STXB1_RAT (1-591): 0: 632: 63.47
+	Hs
		960338 STX1B_HUMAN (1-287): 6.05e-81: 247: 64.81		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Mm
		147920 STX1A_MOUSE (1-287): 5.22e-78: 240: 65.63		STXB1_MOUSE (1-591): 0: 632: 63.47
+	Bt
		746102 STX1A_BOVIN (1-287): 1.23e-77: 239: 64.24		STXB1_BOVIN (1-591): 0: 632: 63.47
+	Rn
		746108 STX1A_RAT (1-287): 7.32e-78: 239: 65.28		STXB1_RAT (1-591): 0: 632: 63.47
+	Hs
		963424 STX1A_HUMAN (1-286): 4.16e-76: 235: 64.46		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Rn
		894400 STX2_RAT (1-265): 4.79e-72: 225: 89.51		STXB1_RAT (1-591): 0: 632: 63.47
+	Hs
		963409 STX4_HUMAN (1-286): 1.24e-60: 196: 42.57		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Hs
		125717 STX2_HUMAN (1-288): 5.72e-82: 250: 100.00		STXB3_HUMAN (1-592): 0: 577: 46.14
+	Dm
		1059140 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		ROP_DROME (4-587): 0: 600: 54.33
+	Ce
		194913 STX1A_CAEEL (2-282): 1.5e-72: 226: 54.77		UNC18_CAEEL (4-588): 0: 588: 52.78
+	Hs
		125737 STX4_HUMAN (1-286): 1.24e-60: 196: 42.57		STXB3_HUMAN (1-592): 0: 577: 46.14
+	Dm
		1172792 STX1A_DROME (2-282): 1.01e-72: 226: 60.56		SLY1_DROME (20-588): 1.3e-136: 413: 17.14
+	Hs
		1087310 STX4_HUMAN (1-286): 1.24e-60: 196: 42.57		VPS45_HUMAN (23-580): 4.98e-147: 437: 21.39
+	Hs
		1087219 STX4_HUMAN (1-286): 1.24e-60: 196: 42.57		SCFD1_HUMAN (7-586): 6.62e-138: 417: 17.97