HitPredict

Interactor 1: STXB1 (O08599)
Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A)
Gene: Stxbp1

Interactor 2: STX1A (O35526)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	36417873, 20114047, 7890599
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin
Common GO terms	GO:0005886 - plasma membrane GO:0010807 - regulation of synaptic vesicle priming GO:0030424 - axon GO:0035493 - SNARE complex assembly GO:0045956 - positive regulation of calcium ion-dependent exocytosis and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 594 Mm			1 288
+	Rn
		746108 STXB1_RAT (1-594): 0: 680: 100.00		STX1A_RAT (1-288): 6.83e-84: 255: 99.65
+	Mm
		147935 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1B_MOUSE (1-288): 2.16e-83: 254: 84.03
+	Bt
		746102 STXB1_BOVIN (1-594): 0: 680: 100.00		STX1A_BOVIN (1-288): 1.3e-83: 254: 97.57
+	Rn
		960333 STXB1_RAT (1-594): 0: 680: 100.00		STX1B_RAT (1-288): 2.16e-83: 254: 84.03
+	Hs
		960338 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1B_HUMAN (1-288): 2.16e-83: 254: 84.03
+	Hs
		963424 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1A_HUMAN (1-287): 5.91e-82: 250: 98.61
+	Hs
		746189 STXB1_HUMAN (1-594): 0: 680: 100.00		STX2_HUMAN (1-288): 5.04e-80: 245: 65.28
+	Mm
		204928 STXB2_MOUSE (1-593): 0: 659: 62.80		STX1A_MOUSE (1-288): 4.87e-84: 255: 100.00
+	Rn
		894400 STXB1_RAT (1-594): 0: 680: 100.00		STX2_RAT (1-266): 6.72e-73: 227: 66.29
+	Hs
		963409 STXB1_HUMAN (1-594): 0: 680: 100.00		STX4_HUMAN (1-287): 2.09e-63: 203: 43.92
+	Hs
		963413 STXB1_HUMAN (1-594): 0: 680: 100.00		STX3_HUMAN (1-288): 1.34e-62: 201: 63.45
+	Rn
		963483 STXB1_RAT (1-594): 0: 680: 100.00		STX3_RAT (1-288): 1.07e-61: 198: 62.41
+	Mm
		147939 STXB1_MOUSE (1-594): 0: 680: 100.00		STX4_MOUSE (1-287): 3.37e-61: 197: 42.91
+	Rn
		963484 STXB1_RAT (1-594): 0: 680: 100.00		STX4_RAT (1-287): 9.1e-61: 196: 42.91
+	Hs
		286641 STXB1_HUMAN (1-594): 0: 680: 100.00		STX11_HUMAN (1-274): 7.29e-54: 178: 29.72
+	Mm
		1000451 STXB2_MOUSE (1-593): 0: 659: 62.80		STX4_MOUSE (1-287): 3.37e-61: 197: 42.91
+	Mm
		1225641 STXB2_MOUSE (1-593): 0: 659: 62.80		STX3_MOUSE (1-264): 6.36e-61: 196: 64.29
+	Hs
		963443 STXB1_HUMAN (1-594): 0: 680: 100.00		STX19_HUMAN (1-264): 3.58e-51: 171: 30.18
+	Rn
		963485 STXB1_RAT (1-594): 0: 680: 100.00		STX5_RAT (2-267): 6.08e-49: 167: 19.16
+	Hs
		286656 STXB2_HUMAN (1-593): 0: 658: 63.47		STX11_HUMAN (1-274): 7.29e-54: 178: 29.72