HitPredict

Interactor 1: PRS6A (P33297)
26S proteasome regulatory subunit 6A (Tat-binding protein homolog 1) (TBP-1)
Gene: RPT5

Interactor 2: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 16284124, 10873636, 9741626, 9584156, 16554755, 16429126, 18467557, 19446323, 37968396, 31848235, 21658604, 22237024, 22615397, 21139140, 22940862
Identification Methods affinity chromatography technology, biochemical, protein complementation assay, cross-linking study, pull down, dihydrofolate reductase reconstruction, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains AAA_lid_3~RPN1_C, AAA_lid_3~RPN1_RPN2_N
Common GO terms GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008540 - proteasome regulatory particle, base subcomplex
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 434
Sc

1 993
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Last updated: 11Aug2025