HitPredict

Interactor 1: A0A087WW66 (A0A087WW66)
26S proteasome non-ATPase regulatory subunit 1
Gene: PSMD1

Interactor 2: PSB5 (P28074)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)
Gene: PSMB5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 914 Hs			1 263
+	Hs
		689 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64
+	Hs
		656760 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSB5_HUMAN (1-263): 2.38e-93: 277: 100.00
+	Hs
		710 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82
+	Hs
		686 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64
+	Hs
		688 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22
+	Hs
		656297 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64
+	Hs
		690 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37
+	Hs
		1303479 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82
+	Hs
		637734 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64
+	Hs
		638180 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22
+	Hs
		656638 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37
+	Dm
		1178951 PSMD1_DROME (2-894): 0: 1056: 58.84		Q7K148_DROME (1-260): 9.47e-85: 256: 51.46
+	Dm
		1359016 PSMD1_DROME (2-894): 0: 1056: 58.84		Q9VUJ1_DROME (62-253): 1.16e-84: 255: 27.08
+	Dm
		1278636 PSMD1_DROME (2-894): 0: 1056: 58.84		PSA5_DROME (28-259): 3.23e-84: 253: 16.67
+	Hs
		656133 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PSB9_HUMAN (55-242): 2.58e-18: 82.8: 30.16
+	Dm
		47613 PSMD1_DROME (2-894): 0: 1056: 58.84		A0AQH0_DROME (42-245): 2.57e-71: 220: 27.81
+	Sc
		689159 RPN2_YEAST (2-914): 0: 919: 38.04		PSA5_YEAST (28-260): 1.87e-80: 244: 17.89
+	Sc
		675399 RPN2_YEAST (2-914): 0: 919: 38.04		PSB5_YEAST (17-257): 9.95e-79: 240: 59.26
+	Sc
		625919 RPN2_YEAST (2-914): 0: 919: 38.04		PSB2_YEAST (53-238): 1.34e-78: 239: 29.03
+	Sc
		693292 RPN2_YEAST (2-914): 0: 919: 38.04		PSB1_YEAST (55-254): 1.48e-70: 217: 26.60