HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 857 Hs			1 196
+	Hs
		988396 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		962091 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67
+	Hs
		978036 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		581072 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RAC2_HUMAN (1-196): 4.54e-77: 230: 53.57
+	Hs
		1015464 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RHOG_HUMAN (1-196): 3.36e-76: 228: 51.53
+	Hs
		466276 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RHOC_HUMAN (1-196): 8.71e-76: 227: 83.16
+	Hs
		955216 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49
+	Hs
		988395 PKN1_HUMAN (49-854): 9.02e-158: 487: 14.84		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		962090 PKN1_HUMAN (49-854): 9.02e-158: 487: 14.84		RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67
+	Hs
		978035 PKN1_HUMAN (49-854): 9.02e-158: 487: 14.84		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		126617 PKN2_HUMAN (49-854): 4.18e-166: 510: 14.12		RHOD_HUMAN (7-182): 3.38e-66: 203: 53.98
+	Hs
		962172 PKN3_HUMAN (49-854): 4.49e-146: 454: 14.95		RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67
+	Hs
		978096 PKN3_HUMAN (49-854): 4.49e-146: 454: 14.95		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Ce
		113580 G5EFX2_CAEEL (61-854): 3.37e-136: 432: 13.16		RAC1_CAEEL (1-196): 3.83e-80: 238: 53.57
+	Ce
		110129 G5EFX2_CAEEL (61-854): 3.37e-136: 432: 13.16		G5EBV3_CAEEL (2-196): 7.16e-76: 227: 48.72
+	Ce
		113581 G5EFX2_CAEEL (61-854): 3.37e-136: 432: 13.16		RHO1_CAEEL (1-196): 4.79e-75: 225: 78.57
+	Hs
		317407 KPCD3_HUMAN (174-853): 4.51e-131: 415: 15.32		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		297098 PAK3_HUMAN (237-805): 1.42e-121: 380: 18.26		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		978279 KPCD2_HUMAN (140-855): 1.38e-118: 382: 14.66		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		297095 PAK3_HUMAN (237-805): 1.42e-121: 380: 18.26		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49