HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: PKN3 (Q6P5Z2)
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)
Gene: PKN3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HR1~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 889
+	Hs
		962172 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		PKN3_HUMAN (1-889): 0: 1041: 100.00
+	Hs
		988395 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PKN1_HUMAN (27-883): 0: 965: 51.05
+	Hs
		962090 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		PKN1_HUMAN (27-883): 0: 965: 51.05
+	Hs
		978035 RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00		PKN1_HUMAN (27-883): 0: 965: 51.05
+	Ce
		113580 RAC1_CAEEL (1-196): 3.83e-80: 238: 53.57		G5EFX2_CAEEL (13-882): 0: 831: 35.20
+	Hs
		728154 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		AKT1_HUMAN (494-883): 5.16e-154: 462: 38.73
+	Hs
		666233 RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00		KPCL_HUMAN (522-886): 1.08e-151: 464: 41.96
+	Dm
		53458 RAC1_DROME (1-196): 9.41e-78: 232: 53.06		PKN_DROME (540-884): 2.69e-121: 398: 60.00
+	Dm
		53474 RAC1_DROME (1-196): 9.41e-78: 232: 53.06		A1Z7T1_DROME (540-884): 3.8e-118: 393: 60.00
+	Sp
		785591 RHO5_SCHPO (4-181): 2.58e-87: 256: 67.98		PCK2_SCHPO (530-884): 1.47e-98: 332: 45.06
+	Sc
		448511 RHO1_YEAST (3-186): 1.42e-88: 260: 67.39		KPC1_YEAST (522-884): 9.86e-96: 327: 44.54
+	Sp
		785582 RHO5_SCHPO (4-181): 2.58e-87: 256: 67.98		PCK1_SCHPO (544-884): 3.8e-94: 320: 46.67
+	Sp
		785585 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		PCK2_SCHPO (530-884): 1.47e-98: 332: 45.06
+	Sp
		785577 RHO1_SCHPO (1-194): 8e-82: 243: 68.21		PCK1_SCHPO (544-884): 3.8e-94: 320: 46.67
+	Rn
		479893 RAC1_RAT (1-196): 1.47e-79: 236: 55.10		KPCD_RAT (555-888): 1.12e-91: 305: 46.90
+	Hs
		961981 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		KPCD_HUMAN (564-886): 1.3e-90: 303: 48.31
+	Hs
		977954 RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00		KPCD_HUMAN (564-886): 1.3e-90: 303: 48.31
+	Hs
		988396 RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10		PKN2_HUMAN (64-261): 2.74e-10: 66.6: 23.74
+	Hs
		962091 RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67		PKN2_HUMAN (64-261): 2.74e-10: 66.6: 23.74
+	Hs
		978036 RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00		PKN2_HUMAN (64-261): 2.74e-10: 66.6: 23.74