HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: C5AR2 (Q9P296)
C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77)
Gene: C5AR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 857 Hs			1 337
+	Hs
		638392 TTK_HUMAN (1-857): 0: 778: 100.00		FPR1_HUMAN (34-326): 4.83e-75: 236: 27.85
+	Hs
		755541 TTK_HUMAN (1-857): 0: 778: 100.00		CXCR4_HUMAN (2-298): 9.13e-72: 228: 22.26
+	Hs
		755535 TTK_HUMAN (1-857): 0: 778: 100.00		CXCR3_HUMAN (1-316): 3.85e-71: 227: 27.96
+	Hs
		755552 TTK_HUMAN (1-857): 0: 778: 100.00		GPR17_HUMAN (36-328): 9.43e-68: 218: 20.78
+	Hs
		755525 TTK_HUMAN (1-857): 0: 778: 100.00		APJ_HUMAN (26-336): 1.39e-65: 213: 23.21
+	Hs
		755527 TTK_HUMAN (1-857): 0: 778: 100.00		OPRX_HUMAN (5-323): 6.09e-60: 198: 22.39
+	Hs
		711590 KPCD2_HUMAN (140-855): 1.38e-118: 382: 14.66		NK3R_HUMAN (1-335): 3.18e-63: 209: 16.90
+	Hs
		638566 M3K4_HUMAN (530-795): 2.2e-22: 105: 27.47		FPR1_HUMAN (34-326): 4.83e-75: 236: 27.85
+	Hs
		886158 M3K4_HUMAN (530-795): 2.2e-22: 105: 27.47		CXCR3_HUMAN (1-316): 3.85e-71: 227: 27.96
+	Hs
		1101721 M3K4_HUMAN (530-795): 2.2e-22: 105: 27.47		GPR17_HUMAN (36-328): 9.43e-68: 218: 20.78