HitPredict

Interactor 1: HRH1 (P35367)
Histamine H1 receptor (H1-R) (H1R) (HH1R)
Gene: HRH1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25517094
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Hs			1 347
+	Hs
		770814 HRH1_HUMAN (1-487): 1.01e-116: 353: 100.00		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		770813 HRH1_HUMAN (1-487): 1.01e-116: 353: 100.00		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		466957 ACM4_HUMAN (5-486): 4.04e-88: 279: 24.54		SH3G3_HUMAN (1-347): 6.72e-91: 277: 100.00
+	Hs
		466956 ACM4_HUMAN (5-486): 4.04e-88: 279: 24.54		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		477196 ADA2A_HUMAN (2-484): 5.29e-82: 263: 19.84		SH3G3_HUMAN (1-347): 6.72e-91: 277: 100.00
+	Mm
		958593 DRD2_MOUSE (1-485): 2.94e-84: 268: 22.87		SH3G2_MOUSE (1-347): 5.19e-86: 265: 65.63
+	Hs
		466855 ACM2_HUMAN (19-485): 9.44e-83: 265: 25.48		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		466955 ACM4_HUMAN (5-486): 4.04e-88: 279: 24.54		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		477195 ADA2A_HUMAN (2-484): 5.29e-82: 263: 19.84		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		612349 ADA2B_HUMAN (36-484): 1.94e-77: 251: 19.61		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		466854 ACM2_HUMAN (19-485): 9.44e-83: 265: 25.48		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		477194 ADA2A_HUMAN (2-484): 5.29e-82: 263: 19.84		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		612348 ADA2B_HUMAN (36-484): 1.94e-77: 251: 19.61		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		771645 DRD3_HUMAN (295-485): 4.88e-33: 131: 23.71		SH3G3_HUMAN (1-347): 6.72e-91: 277: 100.00
+	Hs
		771644 DRD3_HUMAN (295-485): 4.88e-33: 131: 23.71		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		771643 DRD3_HUMAN (295-485): 4.88e-33: 131: 23.71		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		1408405 HRH3_HUMAN (373-483): 1.38e-14: 77.8: 32.14		SH3G2_HUMAN (1-347): 1.33e-86: 266: 65.91
+	Hs
		1408387 HRH3_HUMAN (373-483): 1.38e-14: 77.8: 32.14		SH3G1_HUMAN (1-347): 3.07e-80: 251: 66.03
+	Hs
		771631 DRD3_HUMAN (295-485): 4.88e-33: 131: 23.71		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38
+	Hs
		458368 ADRB2_HUMAN (401-486): 1.94e-25: 109: 37.21		GRB2_HUMAN (290-346): 9.97e-12: 65.5: 41.38