HitPredict

Interactor 1: ARBK2 (P35626)
G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2)
Gene: GRK3

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	39079530
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031623 - receptor internalization GO:0098794 - postsynapse
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 140
+	Hs
		669110 ARBK1_HUMAN (1-688): 0: 615: 84.04		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		791413 GRK1_HUMAN (2-540): 1.93e-144: 434: 31.52		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		728072 AKT1_HUMAN (69-514): 1.82e-143: 429: 28.04		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		733726 GRK4_HUMAN (3-594): 5.63e-142: 428: 33.33		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		791157 GRK6_HUMAN (3-525): 1.68e-140: 424: 37.36		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		761956 GRK5_HUMAN (3-565): 2.68e-139: 422: 33.80		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		1154619 GRK1_HUMAN (2-540): 1.93e-144: 434: 31.52		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		728261 AKT1_HUMAN (69-514): 1.82e-143: 429: 28.04		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		846750 GRK6_HUMAN (3-525): 1.68e-140: 424: 37.36		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		762007 GRK5_HUMAN (3-565): 2.68e-139: 422: 33.80		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		302706 GRK1_HUMAN (2-540): 1.93e-144: 434: 31.52		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		302698 GRK6_HUMAN (3-525): 1.68e-140: 424: 37.36		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		302695 GRK5_HUMAN (3-565): 2.68e-139: 422: 33.80		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00