HitPredict

Interactor 1: GRK4 (P32298)
G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)
Gene: GRK4

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	39079530
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0031623 - receptor internalization
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 578 Hs			1 140
+	Hs
		791157 GRK6_HUMAN (1-577): 0: 527: 65.34		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		761956 GRK5_HUMAN (1-561): 2.64e-175: 510: 67.91		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		846750 GRK6_HUMAN (1-577): 0: 527: 65.34		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		762007 GRK5_HUMAN (1-561): 2.64e-175: 510: 67.91		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		791413 GRK1_HUMAN (3-538): 4.71e-154: 455: 47.32		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		302698 GRK6_HUMAN (1-577): 0: 527: 65.34		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		774819 ARBK2_HUMAN (2-547): 1.5e-149: 447: 35.31		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		669110 ARBK1_HUMAN (2-547): 1.34e-145: 437: 34.41		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		302695 GRK5_HUMAN (1-561): 2.64e-175: 510: 67.91		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		728072 AKT1_HUMAN (142-518): 1.55e-142: 422: 30.87		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		603191 KPCA_HUMAN (12-510): 2.39e-139: 421: 25.39		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		1154619 GRK1_HUMAN (3-538): 4.71e-154: 455: 47.32		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		302706 GRK1_HUMAN (3-538): 4.71e-154: 455: 47.32		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		728261 AKT1_HUMAN (142-518): 1.55e-142: 422: 30.87		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		791321 KPCD_HUMAN (176-468): 5.88e-59: 210: 40.34		SYUA_HUMAN (1-140): 1e-57: 177: 100.00