HitPredict

Interactor 1: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	39079530, 17893145
Identification Methods	two hybrid, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031623 - receptor internalization and 1 others more... GO:0098794 - postsynapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 689 Hs			1 140
+	Hs
		774819 ARBK2_HUMAN (1-686): 0: 640: 83.97		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		791413 GRK1_HUMAN (2-530): 4.78e-147: 441: 32.78		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		728072 AKT1_HUMAN (68-515): 2.86e-144: 431: 26.41		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		791157 GRK6_HUMAN (3-554): 4.63e-141: 426: 35.71		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		733726 GRK4_HUMAN (3-543): 1.14e-140: 425: 34.36		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		791307 KPCE_HUMAN (94-518): 2.16e-137: 422: 23.45		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		761956 GRK5_HUMAN (3-566): 8.34e-139: 421: 33.92		SYUA_HUMAN (1-140): 1e-57: 177: 100.00
+	Hs
		1154619 GRK1_HUMAN (2-530): 4.78e-147: 441: 32.78		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		728261 AKT1_HUMAN (68-515): 2.86e-144: 431: 26.41		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		846750 GRK6_HUMAN (3-554): 4.63e-141: 426: 35.71		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		762007 GRK5_HUMAN (3-566): 8.34e-139: 421: 33.92		SYUB_HUMAN (1-126): 7.62e-37: 124: 58.02
+	Hs
		302706 GRK1_HUMAN (2-530): 4.78e-147: 441: 32.78		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		302698 GRK6_HUMAN (3-554): 4.63e-141: 426: 35.71		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00
+	Hs
		302695 GRK5_HUMAN (3-566): 8.34e-139: 421: 33.92		SYUG_HUMAN (1-100): 1.67e-28: 102: 66.00