Protein: GRK6
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

Gene: GRK6
Organism: Homo sapiens
Interactions: 140
UniProt ID: P43250

Gene Ontology (top 5):
GO:0004703 - G protein-coupled receptor kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

458319

ADRB2
Beta-2 adrenergic receptor

3

9

Small-scale

0.861

High

733487

GP183
G-protein coupled receptor 183

3

13

High-throughput

0.861

High

468158

HS90B
Heat shock protein HSP 90-beta

3

20

Small-scale

0.855

High

733728

GRK4
G protein-coupled receptor kinase 4

3

17

High-throughput

0.855

High

461249

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.847

High

846751

DDB1
DNA damage-binding protein 1

2

6

High-throughput

0.789

High

846738

CD83
CD83 antigen

2

0

High-throughput

0.770

High

846811

CSEN
Calsenilin

1

6

Small-scale

0.747

High

302773

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

9

High-throughput

0.691

High

679088

DNJB1
DnaJ homolog subfamily B member 1

1

13

High-throughput

0.691

High

761962

GRK5
G protein-coupled receptor kinase 5

1

16

High-throughput

0.691

High

846735

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.691

High

846736

DCAF7
DDB1- and CUL4-associated factor 7

1

6

High-throughput

0.691

High

846740

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.691

High

846742

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

846746

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.691

High

846752

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.691

High

846755

DCAF8
DDB1- and CUL4-associated factor 8

1

8

High-throughput

0.691

High

846764

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.691

High

846774

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

11

High-throughput

0.691

High

846783

DNJC7
DnaJ homolog subfamily C member 7

1

12

High-throughput

0.691

High

846786

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.691

High

846729

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.656

High

640496

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.647

High

663517

FSHR
Follicle-stimulating hormone receptor

1

19

Small-scale

0.647

High

846725

GRK6
G protein-coupled receptor kinase 6

1

18

Small-scale

0.647

High

622547

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

10

High-throughput

0.628

High

846747

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

10

High-throughput

0.628

High

846758

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

4

High-throughput

0.628

High

74447

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.618

High

846732

RD23B
UV excision repair protein RAD23 homolog B

1

9

High-throughput

0.618

High

846745

RCN2
Reticulocalbin-2

1

4

High-throughput

0.618

High

846770

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.618

High

846802

AFF4
AF4/FMR2 family member 4

1

3

High-throughput

0.618

High

373823

RASN
GTPase NRas

1

8

High-throughput

0.618

High

375267

RASK
GTPase KRas

1

8

High-throughput

0.618

High

767522

RECO
Recoverin

1

6

Small-scale

0.618

High

846761

RHOU
Rho-related GTP-binding protein RhoU

1

13

High-throughput

0.618

High

846781

MMS19
MMS19 nucleotide excision repair protein homolog

2

1

High-throughput

0.611

High

846765

SMIP4
Sperm-associated microtubule inner protein 4

2

0

High-throughput

0.602

High

846775

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.602

High

846792

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

846777

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.578

High

846753

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

652469

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

15

High-throughput

0.574

High

846744

NUCG
Endonuclease G, mitochondrial

2

2

High-throughput

0.574

High

473673

ITA5
Integrin alpha-5

1

4

High-throughput

0.541

High

124747

AIP
AH receptor-interacting protein

1

20

High-throughput

0.536

High

130026

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.536

High

165019

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

2

High-throughput

0.536

High

172547

XPO1
Exportin-1

1

9

High-throughput

0.536

High

182088

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.536

High

316364

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.536

High

346613

TTC4
Tetratricopeptide repeat protein 4

1

20

High-throughput

0.536

High

359610

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

420417

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

6

High-throughput

0.536

High

483533

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.536

High

608846

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

5

High-throughput

0.536

High

655732

TBG1
Tubulin gamma-1 chain

1

19

High-throughput

0.536

High

697456

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.536

High

698464

CALX
Calnexin

1

2

High-throughput

0.536

High

718373

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.536

High

846726

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.536

High

846730

PPP5
Serine/threonine-protein phosphatase 5

1

16

High-throughput

0.536

High

846733

XPO2
Exportin-2

1

10

High-throughput

0.536

High

846737

PRKDC
DNA-dependent protein kinase catalytic subunit

1

18

High-throughput

0.536

High

846739

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

5

High-throughput

0.536

High

846743

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.536

High

846767

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.536

High

846768

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

2

High-throughput

0.536

High

846772

GCN1
Stalled ribosome sensor GCN1

1

14

High-throughput

0.536

High

846778

AIFM3
Apoptosis-inducing factor 3

1

2

High-throughput

0.536

High

846780

RUFY1
RUN and FYVE domain-containing protein 1

1

20

High-throughput

0.536

High

846782

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

846794

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

846795

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

13

High-throughput

0.536

High

846797

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.536

High

846800

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.536

High

846803

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.536

High

846805

AKP8L
A-kinase anchor protein 8-like

1

4

High-throughput

0.536

High

846807

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

9

High-throughput

0.536

High

846808

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

High-throughput

0.536

High

846809

MAGD2
Melanoma-associated antigen D2

1

8

High-throughput

0.536

High

846810

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.536

High

846815

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

421669

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.515

High

50508

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.513

High

190325

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

774194

BASI
Basigin

1

0

High-throughput

0.513

High

789871

FDFT
Squalene synthase

1

0

High-throughput

0.513

High

846727

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.513

High

846754

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.513

High

846756

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.513

High

846760

FBX38
F-box only protein 38

1

0

High-throughput

0.513

High

846769

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

0

High-throughput

0.513

High

846804

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

846814

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

302698

SYUG
Gamma-synuclein

1

17

Small-scale

0.501

High

791157

SYUA
Alpha-synuclein

1

17

Small-scale

0.501

High

846750

SYUB
Beta-synuclein

1

17

Small-scale

0.501

High

846813

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

124261

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

336888

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.489

High

846728

SERPH
Serpin H1

1

8

High-throughput

0.489

High

846731

LIPR2
Pancreatic lipase-related protein 2

1

1

High-throughput

0.489

High

846748

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

846763

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

10

High-throughput

0.489

High

846790

RPAP3
RNA polymerase II-associated protein 3

1

12

High-throughput

0.489

High

846793

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.489

High

846799

HPBP1
Hsp70-binding protein 1

1

2

High-throughput

0.489

High

846801

DIC
Mitochondrial dicarboxylate carrier

1

11

High-throughput

0.489

High

846812

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.489

High

846734

MLF1
Myeloid leukemia factor 1

1

5

High-throughput

0.479

High

846741

TROP
Trophinin

1

8

High-throughput

0.479

High

846749

MLF2
Myeloid leukemia factor 2

1

5

High-throughput

0.479

High

846773

Q96BE0
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

846787

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

846806

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.458

High

844987

EAA3
Excitatory amino acid transporter 3

1

2

High-throughput

0.445

High

846762

HDGR2
Hepatoma-derived growth factor-related protein 2

1

5

High-throughput

0.445

High

588118

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

694838

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

767613

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

834935

S19A1
Reduced folate transporter

1

0

High-throughput

0.426

High

846785

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.426

High

846796

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

High-throughput

0.426

High

846776

KLH15
Kelch-like protein 15

1

5

High-throughput

0.407

High

846791

PACER
Protein associated with UVRAG as autophagy enhancer

2

0

High-throughput

0.328

High

326243

PRS23
Serine protease 23

1

0

High-throughput

0.282

High

621831

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.279

Low

846757

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

846759

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

846766

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.279

Low

846771

FACR1
Fatty acyl-CoA reductase 1

1

0

High-throughput

0.279

Low

846779

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

846784

METH
Methionine synthase

1

0

High-throughput

0.279

Low

846788

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.279

Low

846789

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

846798

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025