HitPredict

Interactor 1: SOX5 (P35711)
Transcription factor SOX-5
Gene: SOX5

Interactor 2: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 246
+	Hs
		776152 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX13_HUMAN (44-161): 1.52e-30: 120: 14.41
+	Hs
		776030 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX6_HUMAN (49-160): 3.08e-26: 108: 12.82
+	Mm
		776027 SOX5_MOUSE (1-763): 0: 609: 96.86		SOX6_MOUSE (49-160): 7.41e-26: 107: 12.82
+	Hs
		776029 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX5_HUMAN (49-150): 3.73e-24: 102: 12.75
+	Hs
		776133 SOX5_HUMAN (1-763): 0: 611: 100.00		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Hs
		776120 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX7_HUMAN (121-230): 9.38e-20: 89.1: 14.91
+	Hs
		776172 SOX6_HUMAN (14-763): 9.71e-145: 446: 56.21		TFAM_HUMAN (1-246): 2.64e-63: 199: 100.00
+	Hs
		776266 SOX6_HUMAN (14-763): 9.71e-145: 446: 56.21		SOX13_HUMAN (44-161): 1.52e-30: 120: 14.41
+	Hs
		776255 SOX6_HUMAN (14-763): 9.71e-145: 446: 56.21		HM20A_HUMAN (45-146): 9.12e-25: 102: 19.61
+	Mm
		827315 SOX6_MOUSE (14-763): 1.32e-137: 428: 55.91		TOX3_MOUSE (151-223): 5.7e-09: 57.9: 20.78
+	Dm
		1303224 PANG2_DROME (63-630): 9.34e-102: 341: 15.48		Q9VUD3_DROME (144-228): 3.03e-21: 94.1: 20.23
+	Hs
		1462222 SOX13_HUMAN (107-730): 6.24e-75: 256: 41.56		SOX13_HUMAN (44-161): 1.52e-30: 120: 14.41
+	Hs
		141197 SOX1_HUMAN (526-629): 2.39e-40: 155: 46.15		SOX5_HUMAN (49-150): 3.73e-24: 102: 12.75
+	Dm
		120137 PANG1_DROME (243-630): 2.4e-39: 157: 18.04		M9PCG2_DROME (144-228): 3.34e-21: 94.1: 20.23
+	Hs
		873064 SOX9_HUMAN (463-700): 7.18e-45: 170: 26.86		SOX9_HUMAN (140-241): 6.32e-16: 78.3: 15.09
+	Dm
		120230 M9PFG6_DROME (538-638): 1.17e-40: 156: 44.55		M9PCZ7_DROME (147-224): 4.48e-20: 90.6: 25.61
+	Dm
		121514 M9PFG6_DROME (538-638): 1.17e-40: 156: 44.55		DICH_DROME (149-228): 5e-20: 89.4: 23.81